ArticleGastroenterology2020
Famotidine Use Is Associated With Improved Clinical Outcomes in Hospitalized COVID-19 Patients: A Propensity Score Matched Retrospective Cohort Study.
3 registry-linked trialsAbstract read
In one paragraph
Article in Gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 146 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 6 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multi-site, Randomized, Double-Blind, Comparative Trial of the Safety and Efficacy of Standard of Care (SOC) Plus Famotidine vs SOC Plus Placebo for the Treatment of COVID-19 in Hospitalized Adults
Famotidine Use in Non-hospitalized Patients With COVID-19: A Case Series
A Pilot Clinical Evaluation of Astepro® Nasal Spray for Management of Early SARS-CoV-2 Infection
Who cites it
146 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Development of Evidence-Based COVID-19 Management Guidelines for Local Context: The Methodological Challenges.Global health, epidemiology and genomics · 2022Pooled it
- Does Famotidine Reduce the Risk of Progression to Severe Disease, Death, and Intubation for COVID-19 Patients? A Systemic Review and Meta-Analysis.Digestive diseases and sciences · 2021Pooled it
- Lack of Consistent Associations Between Pharmacologic Gastric Acid Suppression and Adverse Outcomes in Patients With Coronavirus Disease 2019: Meta-Analysis of Observational Studies.Gastroenterology · 2021Pooled it
- Effect of famotidine on hospitalized patients with COVID-19: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Histamine receptors and COVID-19.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021Pooled it
- Effect of Acid Suppressants on the Risk of COVID-19: A Propensity Score-Matched Study Using UK Biobank.Gastroenterology · 2021Pooled it
- Role of HWorld journal of clinical cases · 2022Trial
- Histamine receptor 2 blockade selectively impacts B and T cells in healthy subjects.Scientific reports · 2021Trial
- The role of serum tryptase in COVID-19 pathogenesis and its value as a prognostic marker: a single-center prospective cohort study.Acta biochimica Polonica · 2026Article
- Prolactin: A Key Immunoregulator in Viral Infections and Autoimmune Diseases.International journal of endocrinology · 2025Review
- Famotidine increases cellular phospho-tyrosine levels.Biochemical and biophysical research communications · 2024Article
- Unraveling the relevance of SARS-Cov-2 infection and ferroptosis within the heart of COVID-19 patients.Heliyon · 2024Article
- H. Pylori Treatment in the COVID-19 Era. What Have We Learned So Far?Current gastroenterology reports · 2024Review
- GERD: Latest update on acid-suppressant drugs.Current research in pharmacology and drug discovery · 2024Article
- One-year post-acute COVID-19 syndrome and mortality in South Korea: a nationwide matched cohort study using claims data.Frontiers in public health · 2024Article
- Development trends of human organoid-based COVID-19 research based on bibliometric analysis.Cell proliferation · 2023Review
- Carbon dioxide and MAPK signalling: towards therapy for inflammation.Cell communication and signaling : CCS · 2023Review
- Organoids to Remodel SARS-CoV-2 Research: Updates, Limitations and Perspectives.Aging and disease · 2023Review
- Major Shifts in Acid Suppression Drug Utilization After the 2019 Ranitidine Recalls in Canada and United States.Digestive diseases and sciences · 2023Article
- A retrospective analysis of clinical outcomes between hospitalized patients with COVID-19 who received famotidine or pantoprazole.JGH open : an open access journal of gastroenterology and hepatology · 2023Article
86 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on byReply.2021
Authors and funding
7 authors.
Daniel E FreedbergDivision of Digestive and Liver Diseases, Columbia University Irving Medical Center-New York Presbyterian Hospital, New York, New York. Electronic address: def2004@cumc.columbia.edu.
Joseph ConigliaroDivision of General Internal Medicine, Department of Medicine, Northwell Health, Manhasset, New York; Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.
Timothy C WangDivision of Digestive and Liver Diseases, Columbia University Irving Medical Center-New York Presbyterian Hospital, New York, New York.
Kevin J TraceyFeinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
Michael V CallahanDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts; Office of the Assistant Secretary for Public Health Preparedness and Response, U.S. Department of Health and Human Services, Washington, DC.
Julian A AbramsDivision of Digestive and Liver Diseases, Columbia University Irving Medical Center-New York Presbyterian Hospital, New York, New York. Electronic address: ja660@cumc.columbia.edu.
Famotidine Research Group
Funding
Loss of Gastrointestinal Colonization Resistance and Antibiotic-Resistant Infections in the Intensive Care UnitK23DK111847 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FREEDBERG, DANIEL E. · 2017 to 2020
$608kNIDDK NIH HHS K23 DK111847
Abstract
PubMed holds no abstract for this paper.
Indexed as
BetacoronavirusAdultAgedCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentFamotidineFemaleHistamine H2 AntagonistsHumansMaleMiddle AgedPandemicsPneumonia, ViralPropensity ScoreRetrospective StudiesFamotidineHistamine H2 AntagonistsCoronavirus 2019FamotidineHistamine-2 Receptor AntagonistsSARS-CoV-2
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.