Evidence map›Paper›PMID 32446219›Full record

ReviewStem cell research2020

Human pluripotent stem cell-derived cardiac stromal cells and their applications in regenerative medicine.

Martha E Floy, Taylor D Mateyka, Koji L Foreman, Sean P Palecek

Abstract readReview
In one paragraph

Review in Stem cell research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. [Effects of two common acellular methods on the physicochemical properties of dermal acellular matrix].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021
    Article
  5. Developmental lineage of human pluripotent stem cell-derived cardiac fibroblasts affects their functional phenotype.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Martha E FloyDepartment of Chemical and Biological Engineering, University of Wisconsin - Madison, Madison, WI, USA.
Taylor D MateykaDepartment of Chemical and Biological Engineering, University of Wisconsin - Madison, Madison, WI, USA.
Koji L ForemanDepartment of Chemical and Biological Engineering, University of Wisconsin - Madison, Madison, WI, USA.
Sean P PalecekDepartment of Chemical and Biological Engineering, University of Wisconsin - Madison, Madison, WI, USA. Electronic address: sppalecek@wisc.edu.

Funding

Regulating human pluripotent stem cell differentiation by colony confinementR01EB007534 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI PALECEK, SEAN P · 2007 to 2019
$4.1M
A Multi-Omics Approach to Discover Metabolic Critical Quality Attributes for Cardiomyocyte BiomanufacturingR01HL148059 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI PALECEK, SEAN P · 2019 to 2022
$1.5M
NHLBI NIH HHS R01 HL148059NIBIB NIH HHS R01 EB007534
6 · The paper itself

Abstract

Coronary heart disease is one of the leading causes of death in the United States. Recent advances in stem cell biology have led to the development and engineering of human pluripotent stem cell (hPSC)-derived cardiac cells and tissues for application in cellular therapy and cardiotoxicity studies. Initial studies in this area have largely focused on improving differentiation efficiency and maturation states of cardiomyocytes. However, other cell types in the heart, including endothelial and stromal cells, play crucial roles in cardiac development, injury response, and cardiomyocyte function. This review discusses recent advances in differentiation of hPSCs to cardiac stromal cells, identification and classification of cardiac stromal cell types, and application of hPSC-derived cardiac stromal cells and tissues containing these cells in regenerative and drug development applications.

Indexed as

Pluripotent Stem CellsRegenerative MedicineCell DifferentiationHumansMyocytes, CardiacStromal CellsCardiacCardiomyocytesHuman pluripotent stem cellsStromal cells

Identifiers

PMID32446219
PMCPMC7931507

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.