Evidence map›Paper›PMID 32445940›Full record

ArticleLeukemia research2020

DNMT3A alterations associated with myeloid malignancies dictate differential responses to hypomethylating agents.

Heidi L Casellas Román, Kartika Venugopal, Yang Feng, Daniil E Shabashvili, Luisa M Posada, Jianping Li, Olga A Guryanova

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Leukemia research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Alterations toCancer research · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Heidi L Casellas RománDepartment of Pharmacology & Therapeutics, University of Florida College of Medicine, Gainesville, FL, United States; Department of Pharmacology and Toxicology, University of Puerto Rico School of Medicine, Medical Sciences Campus, San Juan, PR, Puerto Rico.
Kartika VenugopalDepartment of Pharmacology & Therapeutics, University of Florida College of Medicine, Gainesville, FL, United States.
Yang FengDepartment of Pharmacology & Therapeutics, University of Florida College of Medicine, Gainesville, FL, United States.
Daniil E ShabashviliDepartment of Pharmacology & Therapeutics, University of Florida College of Medicine, Gainesville, FL, United States.
Luisa M PosadaDepartment of Pharmacology & Therapeutics, University of Florida College of Medicine, Gainesville, FL, United States.
Jianping LiDepartment of Medicine, University of Florida College of Medicine, Gainesville, FL, United States.
Olga A GuryanovaDepartment of Pharmacology & Therapeutics, University of Florida College of Medicine, Gainesville, FL, United States; University of Florida Health Cancer Center, Gainesville, FL, United States. Electronic address: oguryanova@ufl.edu.

Funding

Upstream Regulation and Downstream effectors of c-MYC in Ovarian CancerU54MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Abiel Roche-Lima · 2017 to 2026
$35.8M
Training Program in Regenerative MedicineT32DK074367 · NIDDK · UNIVERSITY OF FLORIDA · PI SCOTT, EDWARD W · 2007 to 2022
$2.9M
The role of DNMT3A mutations in clonal heterogeneity and evolution of hematopoiesisR01DK121831 · NIDDK · UNIVERSITY OF FLORIDA · PI GURYANOVA, OLGA A · 2019 to 2023
$1.7M
Biologic and therapeutic relevance of DNMT3A mutations in acute myeloid leukemiaR00CA178191 · NCI · UNIVERSITY OF FLORIDA · PI GURYANOVA, OLGA A · 2016 to 2018
$759k
NCI NIH HHS R00 CA178191NIDDK NIH HHS R01 DK121831NIDDK NIH HHS T32 DK074367NIMHD NIH HHS U54 MD007600
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA (Cytosine-5-)-MethyltransferasesLeukemia, Myeloid, AcuteMyelodysplastic SyndromesNeoplasm ProteinsAnimalsDecitabineDNA Methyltransferase 3AMiceMice, TransgenicDecitabineDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADnmt3a protein, mouseNeoplasm ProteinsAML(DAC)DecitabineDNA hypomethylating agents (HMA)DNMT3AMDS

Identifiers

PMID32445940
PMCPMC7481860

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.