Evidence map›Paper›PMID 32445737›Full record

SynthesisThe lancet. Diabetes & endocrinology2020

Association of maternal thyroid function with birthweight: a systematic review and individual-participant data meta-analysis.

Arash Derakhshan, Robin P Peeters, Peter N Taylor, Sofie Bliddal, David M Carty, Margreet Meems, Bijay Vaidya, Liangmiao Chen, Bridget A Knight, Farkhanda Ghafoor and 36 more

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The lancet. Diabetes & endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 11 pooled it
18.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 11 syntheses or guidelines pooled it, 241 citations in OpenAlex.

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  4. Risk Factors for Thyroid Dysfunction in Pregnancy: An Individual Participant Data Meta-Analysis.Thyroid : official journal of the American Thyroid Association · 2024
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67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

46 authors at 20 institutions in 13 countries.

Arash DerakhshanDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands; Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, Netherlands.
Robin P PeetersDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands; Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, Netherlands.
Peter N TaylorThyroid Research Group, Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff, UK.
Sofie BliddalDepartment of Medical Endocrinology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
David M CartyDepartment of Diabetes, Endocrinology and Clinical Pharmacology, Glasgow Royal Infirmary, Glasgow, UK; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Margreet MeemsDepartment of Medical and Clinical Psychology, Tilburg University, Tilburg, Netherlands.
Bijay VaidyaDepartment of Endocrinology, Royal Devon and Exeter Hospital National Health Service Foundation Trust, University of Exeter Medical School, Exeter, UK.
Liangmiao ChenDepartment of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Bridget A KnightNational Institute for Health Research Exeter Clinical Research Facility, Royal Devon and Exeter Hospital National Health Service Foundation Trust, University of Exeter Medical School, Exeter, UK.
Farkhanda GhafoorNational Health Research Complex, Shaikh Zayed Medical Complex, Lahore, Pakistan.
Polina V PopovaAlmazov National Medical Research Centre, Saint Petersburg, Russia; Department of Faculty Therapy, St Petersburg Pavlov State Medical University, Saint Petersburg, Russia.
Lorena MossoDepartment of Endocrinology, Pontificia Universidad Catolica de Chile, Santiago, Chile.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School, Boston, MA, USA; Harvard Pilgrim Health Care Institute, Boston, MA, USA; Department of Nutrition, Harvard T H Chan School of Public Health, Boston, MA, USA.
Eila SuvantoDepartment of Obstetrics and Gynecology, University of Oulu, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Aya HisadaCenter for Preventive Medical Sciences, Chiba University, Chiba, Japan.
Jun YoshinagaFaculty of Life Sciences, Toyo University, Gunma, Japan.
Suzanne J BrownDepartment of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Judit BassolsMaternal-Fetal Metabolic Research Group, Girona Biomedical Research Institute (IDIBGI), Dr Josep Trueta Hospital, Girona, Spain.
Juha AuvinenCenter for Life Course Health Research, University of Oulu, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Wichor M BramerMedical Library, Erasmus University Medical Center, Rotterdam, Netherlands.
Abel López-BermejoPediatric Endocrinology Research Group, Girona Biomedical Research Institute (IDIBGI), Dr Josep Trueta Hospital, Girona, Spain.
Colin M DayanThyroid Research Group, Institute of Molecular and Experimental Medicine, School of Medicine, Cardiff University, Cardiff, UK.
Robert FrenchSchool of Medicine, Cardiff University, Cardiff, UK; Centre for Multilevel Modelling, University of Bristol, Bristol, UK.
Laura BoucaiDepartment of Medicine, Division of Endocrinology, Memorial Sloan-Kettering Cancer Center, Weill Cornell University, New York, NY, USA.
Marina VafeiadiDepartment of Social Medicine, University of Crete, Heraklion, Greece.
Elena N GrinevaAlmazov National Medical Research Centre, Saint Petersburg, Russia; Department of Faculty Therapy, St Petersburg Pavlov State Medical University, Saint Petersburg, Russia.
Victor J M PopDepartment of Medical and Clinical Psychology, Tilburg University, Tilburg, Netherlands.
Tanja G VrijkotteDepartment of Public Health, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, Netherlands.
Leda ChatziDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, CA, USA.
Jordi SunyerISGlobal, Barcelona, Spain; Pompeu Fabra University, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
Ana Jiménez-ZabalaBiodonostia Health Research Institute, San Sebastian, Spain; Public Health Division of Gipuzkoa, Basque Government, San Sebastian, Spain.
Isolina RiañoSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Department of Pediatrics, Hospital Universitario Central de Asturias (Oviedo), Spain.
Marisa RebagliatoSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; School of Medicine, Universitat Jaume I, Castelló de la Plana, Spain.
Xuemian LuDepartment of Endocrinology, Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Amna PirzadaShifa College of Medicine, Islamabad, Pakistan.
Tuija MännistöMedical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Northern Finland Laboratory Center Nordlab, Oulu University Hospital and University of Oulu, Oulu, Finland.
Christian DellesInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Ulla Feldt-RasmussenDepartment of Medical Endocrinology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Erik K AlexanderDivision of Endocrinology, Hypertension and Diabetes, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Scott M NelsonSchool of Medicine, University of Glasgow, Glasgow, UK; National Institute for Health Research, Bristol Biomedical Research Centre, Bristol, UK.
Layal ChakerDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands; Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, Netherlands.
Elizabeth N PearceSection of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, MA, USA.
Mònica GuxensISGlobal, Barcelona, Spain; Pompeu Fabra University, Barcelona, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain; Department of Child and Adolescent Psychiatry/ Psychology, Erasmus University Medical Centre-Sophia Children's Hospital, Rotterdam, Netherlands.
Eric A P SteegersDepartment of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, Netherlands.
John P WalshDepartment of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia; Medical School, University of Western Australia, Crawley, WA, Australia.
Tim I M KorevaarDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands; Academic Center for Thyroid Diseases, Erasmus University Medical Center, Rotterdam, Netherlands. Electronic address: t.korevaar@erasmusmc.nl.
Erasmus MC · NLCardiff University · GBFederal Almazov North-West Medical Research Centre · RUHarvard University · USInstitut d'Investigació Biomèdica de Girona · ESOulu University Hospital · FISir Charles Gairdner Hospital · AUTilburg University · NLUniversity of Glasgow · GBBasque Government · ESBoston University · USChiba University · JPCopenhagen University Hospital · DKHospital del Mar Research Institute · ESInstituto de Salud Carlos III · ESMemorial Sloan Kettering Cancer Center · USNIHR Bristol Biomedical Research Centre · GBNIHR Exeter Clinical Research Facility · GBPontificia Universidad Católica de Chile · CLRigshospitalet · DK

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Medical Research Council MR/N015428/1NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundAdequate transplacental passage of maternal thyroid hormone is important for normal fetal growth and development. Maternal overt hypothyroidism and hyperthyroidism are associated with low birthweight, but important knowledge gaps remain regarding the effect of subclinical thyroid function test abnormalities on birthweight-both in general and during the late second and third trimester of pregnancy. The aim of this study was to examine associations of maternal thyroid function with birthweight.

methodsIn this systematic review and individual-participant data meta-analysis, we searched MEDLINE (Ovid), Embase, Web of Science, the Cochrane Central Register of Controlled Trials, and Google Scholar from inception to Oct 15, 2019, for prospective cohort studies with data on maternal thyroid function during pregnancy and birthweight, and we issued open invitations to identify study authors to join the Consortium on Thyroid and Pregnancy. We excluded participants with multiple pregnancies, in-vitro fertilisation, pre-existing thyroid disease or thyroid medication usage, miscarriages, and stillbirths. The main outcomes assessed were small for gestational age (SGA) neonates, large for gestational age neonates, and newborn birthweight. We analysed individual-participant data using mixed-effects regression models adjusting for maternal age, BMI, ethnicity, smoking, parity, gestational age at blood sampling, fetal sex, and gestational age at birth. The study protocol was pre-registered at the International Prospective Register of Systematic Reviews, CRD42016043496.

findingsWe identified 2526 published reports, from which 36 cohorts met the inclusion criteria. The study authors for 15 of these cohorts agreed to participate, and five more unpublished datasets were added, giving a study population of 48 145 mother-child pairs after exclusions, of whom 1275 (3·1%) had subclinical hypothyroidism (increased thyroid stimulating hormone [TSH] with normal free thyroxine [FT

interpretationMaternal subclinical hypothyroidism in pregnancy is associated with a higher risk of SGA and lower birthweight, whereas isolated hypothyroxinaemia is associated with lower risk of SGA and higher birthweight. There was an inverse, dose-response association of maternal TSH and FT

fundingNetherlands Organization for Scientific Research (grant 401.16.020).

Indexed as

Birth WeightFemaleGestational AgeHumansHypothyroidismInfant, Low Birth WeightInfant, NewbornPregnancyPregnancy ComplicationsThyroid Function TestsThyroid Gland

Identifiers

PMID32445737
PMCPMC8168324
OpenAlexW3017278609

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.