Evidence map›Paper›PMID 32445489›Full record

SynthesisJournal of medical virology2020

COVID-19 and liver dysfunction: A systematic review and meta-analysis of retrospective studies.

Mohanad Youssef, Mohammad H Hussein, Abdallah S Attia, Rami M Elshazli, Mahmoud Omar, Ghassan Zora, Ashraf S Farhoud, Ahmad Elnahla, Areej Shihabi, Eman A Toraih and 2 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of medical virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  6. Is liver involvement overestimated in COVID-19 patients? A meta-analysis.International journal of medical sciences · 2021
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  16. Current Views About the Link between SARS-CoV-2 and the Liver: Friends or Foe?Endocrine, metabolic & immune disorders drug targets · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mohanad YoussefDepartment of Surgery, Tulane University, School of Medicine, New Orleans, Louisiana.
Mohammad H HusseinDepartment of Surgery, Tulane University, School of Medicine, New Orleans, Louisiana.ORCID 0000-0001-8278-7094
Abdallah S AttiaDepartment of Surgery, Tulane University, School of Medicine, New Orleans, Louisiana.ORCID 0000-0003-2163-0637
Rami M ElshazliDepartment of Biochemistry and Molecular Genetics, Faculty of Physical Therapy, Horus University-Egypt, New Damietta, Egypt.ORCID 0000-0002-3381-2641
Mahmoud OmarDepartment of Surgery, Tulane University, School of Medicine, New Orleans, Louisiana.ORCID 0000-0001-7917-7973
Ghassan ZoraDepartment of Surgery, Tulane University, School of Medicine, New Orleans, Louisiana.ORCID 0000-0002-4586-1918
Ashraf S FarhoudDepartment of Surgery, Tulane University, School of Medicine, New Orleans, Louisiana.
Ahmad ElnahlaDepartment of Surgery, Tulane University, School of Medicine, New Orleans, Louisiana.ORCID 0000-0002-6973-5561
Areej ShihabiDepartment of Surgery, Tulane University, School of Medicine, New Orleans, Louisiana.
Eman A ToraihDepartment of Surgery, Tulane University, School of Medicine, New Orleans, Louisiana.ORCID 0000-0001-9267-3787
Manal S FawzyDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.ORCID 0000-0003-1252-8403
Emad KandilDivision of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University, School of Medicine, New Orleans, Louisiana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, Coronavirus Disease 2019 (COVID-19) pandemic is the most significant global health crisis. In this study, we conducted a meta-analysis to find the association between liver injuries and the severity of COVID-19 disease. Online databases, including PubMed, Web of Science, Scopus, and Science direct, were searched to detect relevant publications up to 16 April 2020. Depending on the heterogeneity between studies, a fixed- or random-effects model was applied to pool data. Publication bias Egger's test was also performed. Meta-analysis of 20 retrospective studies (3428 patients), identified that patients with a severe manifestation of COVID-19 exhibited significantly higher levels of alanine aminotransferase, aspartate aminotransferase, and bilirubin values with prolonged prothrombin time. Furthermore, lower albumin level was associated with a severe presentation of COVID-19. Liver dysfunction was associated with a severe outcome of COVID-19 disease. Close monitoring of the occurrence of liver dysfunction is beneficial in early warning of unfavorable outcomes.

Indexed as

Alanine TransaminaseAspartate AminotransferasesBilirubinCOVID-19HumansLiverLiver DiseasesProthrombin TimeAlanine TransaminaseAspartate AminotransferasesBilirubinCOVID-19liver functionmeta-analysisoutcomeSARS-CoV-2

Identifiers

PMID32445489
PMCPMC7283797

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.