Evidence map›Paper›PMID 32445474›Full record

Trial reportClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020

Impact of Intrapartum Oral Azithromycin on the Acquired Macrolide Resistome of Infants' Nasopharynx: A Randomized Controlled Trial.

Abdoulie Bojang, Sarah L Baines, Bully Camara, Romain Guerillot, Liam Donovan, Raquel Sánchez Marqués, Ousman Secka, Umberto D'Alessandro, Christian Bottomley, Benjamin P Howden and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Abdoulie BojangMedical Research Council Unit, The Gambia, at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Sarah L BainesDepartment of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Bully CamaraMedical Research Council Unit, The Gambia, at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Romain GuerillotDepartment of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Liam DonovanDepartment of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Raquel Sánchez MarquésMedical Research Council Unit, The Gambia, at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Ousman SeckaMedical Research Council Unit, The Gambia, at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Umberto D'AlessandroMedical Research Council Unit, The Gambia, at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.
Christian BottomleyTropical Epidemiology Group, London School of Hygiene and Tropical Medicine, United Kingdom.
Benjamin P HowdenDepartment of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Anna RocaMedical Research Council Unit, The Gambia, at the London School of Hygiene and Tropical Medicine, Fajara, The Gambia.

Funding

Medical Research Council MC_EX_MR/J010391/1
6 · The paper itself

Abstract

In a post hoc analysis of samples from an intrapartum azithromycin randomized clinical trial, we found that children whose mothers had been treated with the drug had higher prevalence of macrolide-resistance genes msr(A) and ermC at 28 days but not at 12 months. The 2 genes were positively associated in the nasopharynx. CLINICAL TRIALS REGISTRATION: NCT1800942.

Indexed as

AzithromycinMacrolidesAnti-Bacterial AgentsChildDrug Resistance, BacterialHumansInfantNasopharynxPrevalenceAnti-Bacterial AgentsAzithromycinMacrolidesazithromycinermCmsr(A)NPSThe Gambia

Identifiers

PMID32445474
PMCPMC7819521

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.