Evidence map›Paper›PMID 32445294›Full record

ArticleJournal of clinical laboratory analysis2020

The up-regulated hsa-circRNA9102-5 may be a risk factor for essential hypertension.

Shuying Zheng, Xin He, Jihan Sun, Qiang Li, Tao Zhang, Lina Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Review
  5. Review
  6. Review
  7. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Shuying ZhengDepartment of Preventative Medicine, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Medicine School of Ningbo University, Ningbo, China.
Xin HeDepartment of Preventative Medicine, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Medicine School of Ningbo University, Ningbo, China.
Jihan SunDepartment of Clinical Medicine, Medicine School of Ningbo University, Ningbo, China.
Qiang LiDepartment of Radiology, Yinzhou People's Hospital, Ningbo, China.
Tao ZhangDepartment of Chronic Disease Control and Prevention, Ningbo Municipal Center for Disease Control and Prevention, Ningbo, China.
Lina ZhangDepartment of Preventative Medicine, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Medicine School of Ningbo University, Ningbo, China.ORCID https://orcid.org/0000-0003-4904-3389
Ningbo University · CNNingbo Center for Disease Control and Prevention · CN

Funding

KC Wong Magna Fund in Ningbo UniversityNational Natural Science Foundation of China 81773528Ningbo Scientific Innovation Team for Environmental Hazardous Factor Control and Prevention 2016C51001
6 · The paper itself

Abstract

backgroundThe present study was aimed to investigate the expression levels of circular RNAs (circRNAs) in the peripheral blood of essential hypertension (EH) patients and healthy controls (HC). On this basis, we tried to explain the possible role of circRNAs in the progression of EH and their potential as diagnostic biomarkers of EH.

methodsFirst, we analyzed the differentially expressed circRNAs in peripheral blood obtained from the finished microarray analysis and selected four circRNAs under strict standards. Then, quantitative real-time polymerase chain reaction (qRT-PCR) was performed to measure the expression levels of the selected circRNAs in a total of 192 blood samples, consisting of 96 HC and 96 diagnosed EH patients. Bioinformatics prediction of the target microRNAs (miRNAs) was performed for differentially expressed circRNAs, and the circulating vascular-related miRNAs were selected for qRT-PCR analysis to determine their expression levels.

resultsHsa-circRNA9102-5 (11.7 ± 1.06 vs 12.13 ± 1.11, P = .007) was up-regulated in the patients group which was diagnosed with EH, as compared to the HC group, and was involved in the regulation of EH by sponging hsa-miR-150-5p. The area under the ROC curve (AUC) of the model was 0.620, using hsa-circRNA9102-5 as an independent predictor. Furthermore, the AUC was increased to 0.728 when hsa-circRNA9102-5 was combined with hsa-miR-150-5p and multiple other factors, as a combined predictor.

conclusionsThe present results suggested that hsa-circRNA9102-5 may have played a crucial role in the development of EH by sponging hsa-miR-150-5p, which showed great potential as a novel target.

Indexed as

Essential HypertensionRNA, CircularAdultCase-Control StudiesFemaleHumansMaleMicroRNAsMiddle AgedRisk FactorsROC CurveUp-RegulationMicroRNAsMIR150, humanRNA, Circularbiological functionbiomarkercircular RNAessential hypertensiongene expression

Identifiers

PMID32445294
PMCPMC7439346
OpenAlexW3026423597

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.