ArticleTropical animal health and production2020
Intrauterine therapy with ozone reduces subclinical endometritis and improves reproductive performance in postpartum dairy cows managed in pasture-based systems.
Article in Tropical animal health and production, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Evidence and Clinical Applications of Natural Products in Veterinary Medicine: A Systematic Review of Clinoptilolite, Ozone Therapy, Propolis, and Phytotherapy.Veterinary sciences · 2026Review
- Endometrial gland remodeling and preserved luminal ultrastructure in postpartum cows infused with ozonated sunflower oil.Animal reproduction · 2026Article
- Exploring the influence of endometritis diagnostic criteria on uterine involution, milk yield and fertility in dairy cows.BMC veterinary research · 2025Article
- Fundamentals of microbiome-based therapies for reproductive tract inflammatory diseases in domestic animals.Animal reproduction · 2025Review
- The curative effect of ozonated bidistilled water on Escherichia coli-induced endometritis in rats.Veterinary medicine and science · 2023Article
- In Vitro Activity of Ozone/Oxygen Gaseous Mixture against a Caprine Herpesvirus Type 1 Strain Isolated from a Goat with Vaginitis.Animals : an open access journal from MDPI · 2023Article
- Evidence for the Use of Complementary and Alternative Medicine for Pelvic Inflammatory Disease: A Literature Review.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Ozone and its derivatives in veterinary medicine: A careful appraisal.Veterinary and animal science · 2021Review
- Recent advances and future directions for uterine diseases diagnosis, pathogenesis, and management in dairy cows.Animal reproduction · 2020Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
New postpartum strategies have been developed in dairy cows to ameliorate uterine health and reproductive performance, especially the first service conception rates. This study aimed to assess the effect of intrauterine therapy with ozone (IUTO) in early postpartum on subclinical endometritis prevalence and reproductive parameters in dairy cows under commercial farm conditions. For this purpose, eighty clinically healthy cows with a body condition score between 3.0 and 3.5, from four dairy farms, were randomly allocated into two groups: ozone therapy group (OG, n = 40), which were subjected to IUTO, and control group (CG, n = 40). Content of uterine polymorphonuclear (PMN) leukocytes and subclinical endometritis (SE) percentage were assessed at 35 days after calving by uterine cytology. A second cytology was performed 72 h after IUTO. Reproductive parameters such as interval calving to first service (IFS), number of services per conception (nSC), interval calving to conception (ICC) and first service conception rate (FSCR) were analysed. The second endometrial cytology demonstrated that IUTO reduced (P < 0.01) both PMN (3.7 ± 1.4 vs. 7.6 ± 1.1%) and SE (5.0 vs. 50.0%) percentages compared with CG. Likewise, after ozone treatment, both nSC (2.1 ± 0.3 vs. 3.1 ± 0.2; P < 0.01) and ICC (126.2 ± 9.7 vs. 149.0 ± 9.0; P = 0.0672) decreased, and FSCR increased (50.0 vs. 16.2%; P < 0.01) compared with CG. In conclusion, intrauterine ozone therapy applied at 35 days after calving reduced subclinical endometritis prevalence and improved reproductive performance in postpartum dairy cows managed in a pasture-based system.
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Registered trials
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