Evidence map›Paper›PMID 32445067›Full record

SynthesisArchives of gynecology and obstetrics2020

Neonatal outcomes in singleton pregnancies conceived by fresh or frozen embryo transfer compared to spontaneous conceptions: a systematic review and meta-analysis.

Flavia T S Elias, Danielle Weber-Adrian, Jessica Pudwell, Jillian Carter, Mark Walker, Laura Gaudet, Graeme Smith, Maria P Velez

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Archives of gynecology and obstetrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 6 pooled it
18.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 6 syntheses or guidelines pooled it, 78 citations in OpenAlex.

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  20. Birth size after embryo cryopreservation: larger by all measures?Human reproduction (Oxford, England) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Flavia T S EliasDepartment of Obstetrics and Gynecology, Kingston General Hospital, Queen's University, Kingston, ON, K7L 2V7, Canada.ORCID 0000-0002-7142-6266
Danielle Weber-AdrianDepartment of Obstetrics and Gynecology, Kingston General Hospital, Queen's University, Kingston, ON, K7L 2V7, Canada.
Jessica PudwellDepartment of Obstetrics and Gynecology, Kingston General Hospital, Queen's University, Kingston, ON, K7L 2V7, Canada.
Jillian CarterDepartment of Obstetrics and Gynecology, Kingston General Hospital, Queen's University, Kingston, ON, K7L 2V7, Canada.
Mark WalkerDepartment of Obstetrics, Gynecology and Newborn Care, University of Ottawa, Ottawa, ON, K1H 8M5, Canada.
Laura GaudetDepartment of Obstetrics and Gynecology, Kingston General Hospital, Queen's University, Kingston, ON, K7L 2V7, Canada.
Graeme SmithDepartment of Obstetrics and Gynecology, Kingston General Hospital, Queen's University, Kingston, ON, K7L 2V7, Canada.
Maria P VelezDepartment of Obstetrics and Gynecology, Kingston General Hospital, Queen's University, Kingston, ON, K7L 2V7, Canada. maria.velez@queensu.ca.ORCID 0000-0003-4834-8279
Queen's University · CAUniversity of Ottawa · CA

Funding

CIHR Grant MFM-146444
6 · The paper itself

Abstract

purposeThe use of assisted reproductive technology (ART) has increased in the last 2 decades and continuous surveillance is needed. This systematic review aims to assess the risk of adverse neonatal outcomes (preterm birth [PTB], low birth weight [LBW], small-for-gestationalage [SGA] and large for gestational-age [LGA]), in singleton pregnancies conceived by fresh or frozen embryo transfer (FET) compared to spontaneous conceptions.

methodsCohort studies were identified from MEDLINE, Embase, Cochrane Library (January 2019), and manual search. Meta-analyses were performed to estimate odds ratios (OR) using random effects models in RevMan 5.3 and I-squared (I

resultsAfter 3142 titles and abstracts were screened, 1180 full-text articles were assessed, and 14 were eligible. For fresh embryo transfer, the pooled ORs were PTB 1.64 (95% CI 1.46, 1.84); I

conclusionsWhen compared with spontaneous pregnancies, fresh, but not frozen was associated with LBW and SGA. Both fresh and frozen were associated with PTB. Frozen was uniquely associated with LGA. Despite improvements in ART protocols in relation to pregnancy rates, attention is needed towards monitoring adverse neonatal outcomes in these pregnancies.

Indexed as

FertilizationReproductive Techniques, AssistedCohort StudiesCryopreservationEmbryo TransferFemaleFetal Growth RetardationHumansInfant, Low Birth WeightInfant, NewbornInfertilityPregnancyPregnancy OutcomePregnancy RatePremature BirthTreatment OutcomeAdverse neonatal outcomesAssisted reproductive technologyFresh embryo transferFrozen embryo transferMeta-analysisReal-world data

Identifiers

PMID32445067
PMCPMC7266861
OpenAlexW3026942373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.