ArticlePsychopharmacology2020
Ablation of olfactory bulb glutamatergic neurons induces depressive-like behaviors and sleep disturbances in mice.
Article in Psychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
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- Cholinergic interneurons in the shell region of the nucleus accumbens regulate binge alcohol consumption: A chemogenetic and genetic lesion study.Alcohol, clinical & experimental research · 2024Article
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- Olfactory bulb anomalies in KBG syndrome mouse model and patients.BMC medicine · 2024Article
- Potential neural substrates underlying circadian and olfactory disruptions in preclinical Alzheimer's disease.Frontiers in neuroscience · 2023Review
- A cluster of mesopontine GABAergic neurons suppresses REM sleep and curbs cataplexy.Cell discovery · 2022Article
- Similar patterns of [European journal of nuclear medicine and molecular imaging · 2022Article
- Inhibition of Hippocampal Neurogenesis Starting in Adolescence Increases Anxiodepressive Behaviors Amid Stress.Frontiers in behavioral neuroscience · 2022Article
- Differences in Evolution of Epileptic Seizures and Topographical Distribution of Tissue Damage in Selected Limbic Structures Between Male and Female Rats Submitted to the Pilocarpine Model.Frontiers in neurology · 2022Article
- Article
- Prenatal stress induced depressive-like behavior and region dependently high CRP level in offspring rats.Brain and behavior · 2021Article
- New Horizons for Phenotyping Behavior in Rodents: The Example of Depressive-Like Behavior.Frontiers in behavioral neuroscience · 2021Review
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleMajor depression is a serious, but common, psychological disorder, which consists of a long-lasting depressive mood, feelings of helplessness, anhedonia, and sleep disturbances. It has been reported that rats with bilateral olfactory bulbectomies (OBXs) exhibit depressive-like behaviors which indicates that the olfactory bulb (OB) plays an important role in the formation of depression. However, which type of OB neurons plays an important role in the formation of depression remains unclear.
objectiveTo determine the role of OB neuronal types in depression and related sleep-wake dysfunction.
methodsFirstly, we established and evaluated a conventional physical bilateral OBX depression model. Secondly, we used chemical methods to ablate OB neurons, while maintaining the original shape, and evaluated depressive-like behaviors. Thirdly, we utilized AAV-flex-taCasp3-TEVp and transgenetic mice to specifically ablate the OB GABAergic or glutamatergic neurons, then evaluated depressive-like behaviors.
resultsCompared with measured parameters in sham mice, mice with OBXs or ibotenic acid-induced OB lesions exhibited depressive-like behaviors and sleep disturbances, as demonstrated by results of depressive-like behavior tests and sleep recordings. Selective lesioning of OB glutamatergic neurons, but not GABAergic neurons induced depressive-like behaviors and increased rapid eye movement sleep during the light phase of the circadian cycle.
conclusionsThese results indicate that OB glutamatergic neurons play a key role in olfactory-related depression and sleep disturbance.
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