Evidence map›Paper›PMID 32445017›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2020

The long-term effect of human immunodeficiency virus infection on retinal microvasculature and the ganglion cell-inner plexiform layer: an OCT angiography study.

Berkay Akmaz, Fahrettin Akay, Yusuf Ziya Güven, Figen Kaptan, Tuna Demirdal

Abstract read
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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Optical coherence tomography angiography measurements in patients with HIV: a systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025
    Pooled it
  2. Association between human immunodeficiency virus infection and the risk of glaucoma: a real-world multicenter cohort study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
  3. Layer-by-layer macular, peripapillary retinal nerve fiber layer thickness and minimum rim width changes in PLWH with undetectable viral load: an OCT-based study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
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  7. Reduced macular vessel density in COVID-19 patients with and without associated thrombotic events using optical coherence tomography angiography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Berkay AkmazDepartment of Ophthalmology, İzmir Katip Çelebi University Atatürk Training and Research Hospital, 35200, İzmir, Turkey.
Fahrettin AkayDepartment of Ophthalmology, İzmir Katip Çelebi University Atatürk Training and Research Hospital, 35200, İzmir, Turkey. drfakay@yahoo.com.
Yusuf Ziya GüvenDepartment of Ophthalmology, İzmir Katip Çelebi University Atatürk Training and Research Hospital, 35200, İzmir, Turkey.
Figen KaptanDepartment of Infectious Diseases, İzmir Katip Çelebi University Atatürk Training and Research Hospital, İzmir, Turkey.
Tuna DemirdalDepartment of Infectious Diseases, İzmir Katip Çelebi University Atatürk Training and Research Hospital, İzmir, Turkey.
Izmir Kâtip Çelebi University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the long-term effect of HIV infection on the ganglion cell-inner plexiform layer and retinal capillary network.

methodsThis prospective, cross-sectional case-control study included 45 HIV-infected patients and 45 healthy individuals. Optical coherence tomography angiography (OCTA) was used for the assessment of macular, peripapillary retinal nerve fiber layer (RNFL) thicknesses, ganglion cell-inner plexiform layer, vessel density, perfusion density, and foveal avascular zone.

resultsThe mean disease duration was 7.3 ± 1.9 years (range, 5-12 years) in the HIV group. The mean CD4 count (nadir) for all the patients was 147.09 ± 122 cells/mm

conclusionsThe results of this study provide evidence of microvascular and neuroretinal loss in individuals with well-suppressed HIV infection, compared with healthy control subjects. OCTA is an important test for the screening of retinal microvascular changes over time in HIV-infected cases.

Indexed as

HIVAdultCase-Control StudiesCross-Sectional StudiesEye Infections, ViralFemaleFluorescein AngiographyFollow-Up StudiesFundus OculiHIV InfectionsHumansMaleMicrovesselsNerve FibersProspective StudiesRetinal Ganglion CellsGC-IPLHIV infectionMaculaRetinal capillaryRNFL

Identifiers

PMID32445017
OpenAlexW3026442164

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.