Evidence map›Paper›PMID 32445016›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2020

Pattern dystrophy-like changes and coquille d'oeuf atrophy in elderly patients affected by pseudoxanthoma elasticum.

Vittoria Murro, Dario Pasquale Mucciolo, Dario Giorgio, Andrea Sodi, Federica Boraldi, Daniela Quaglino, Gianni Virgili, Fabrizio Giansanti

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. A Case Report ofDiagnostics (Basel, Switzerland) · 2021
    Article
  3. Article
  4. Dermal Alterations in Clinically Unaffected Skin ofJournal of clinical medicine · 2021
    Article
  5. Fundus Autofluorescence and Clinical Applications.Journal of ophthalmic & vision research
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Vittoria MurroDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Dario Pasquale MuccioloDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy. dario.mucciolo@gmail.com.ORCID http://orcid.org/0000-0002-1661-5312
Dario GiorgioDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Andrea SodiDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Federica BoraldiDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Daniela QuaglinoDepartment of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Gianni VirgiliDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Fabrizio GiansantiDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
University of Florence · ITUniversity of Modena and Reggio Emilia · ITAzienda Ospedaliero-Universitaria Careggi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the retinal features of elderly patients affected by pseudoxanthoma elasticum (PXE). MATERIALS AND

methodsThis is a retrospective case series of 62 eyes of 31 elderly PXE patients (age > 50 years). Clinical data, ultra-widefield fundus imaging (color, red-free (RF), infra-red imaging (IR), fundus autofluorescence (FAF)), and OCT examinations were collected. Diagnosis was confirmed by genetic testing or skin biopsy.

resultsThirty-one patients (10 males and 21 females (mean age 61.3 years, range 50-74 years)) were included in our study. Visual acuity ranged from 20/20 Snellen equivalent to 20/200. The mean follow-up was 66.4 ± 20.7 months (range 10-88). Pattern dystrophy-like changes (PD) (52 eyes of 26 patients, 83.8%) and atrophy resembling the "diffuse trickling" pattern described in geographic atrophy were present in the majority of patients. Twenty-three eyes of 12 patients (67.6%) had peripapillary atrophy, 9 eyes of 5 patients (26.4%) macular atrophy, 6 eyes of 3 patients (17.6%) displayed posterior pole atrophy and in 6 eyes of 3 patients (17.6%), atrophy could be detected beyond the vascular arcades (mid-peripheral atrophy). End-stage atrophy covered the entire area indicated as "coquille d'oeuf" (eggshell). Choroidal neovascularization occurred in 49 eyes of 26 patients (94.2%) with PD and in 6 eyes of 3 patients (60%) without PD. Genetic examinations were available for 29 patients (29/31, 93.5%).

conclusionsThe elderly PXE patients were characterized by pattern dystrophy-like changes with more or less extensive atrophy, progressive over time, which in some cases affected the whole area of the coquille d'oeuf during the course of the disease.

Indexed as

Visual AcuityAgedAtrophyBruch MembraneDisease ProgressionFemaleFluorescein AngiographyFollow-Up StudiesFundus OculiHumansMaleMiddle AgedPrognosisPseudoxanthoma ElasticumRetinaRetrospective StudiesAngioid streakAtrophyBruch’s membraneCoquille d’oeufElderlyOCTPXEWidefield imaging

Identifiers

PMID32445016
OpenAlexW3026391028

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.