Evidence map›Paper›PMID 32445005›Full record

ReviewJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2020

Reciprocal Influences of HIV and Cannabinoids on the Brain and Cognitive Function.

Sheri L Towe, Christina S Meade, Christine C Cloak, Ryan P Bell, Julian Baptiste, Linda Chang

Abstract readReview
In one paragraph

Review in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. HIV and Substance Use in Latin America: A Scoping Review.International journal of environmental research and public health · 2022
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Unraveling neuroHIV in the Presence of Substance Use Disorders.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sheri L ToweDepartment of Psychiatry & Behavioral Sciences, Duke University School of Medicine, Durham, NC, 27705, USA.ORCID 0000-0002-3447-5384
Christina S MeadeDepartment of Psychiatry & Behavioral Sciences, Duke University School of Medicine, Durham, NC, 27705, USA.ORCID 0000-0002-0864-1123
Christine C CloakDiagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 670 W. Baltimore Street, HSF III, Room 1161, Baltimore, MD, 21201, USA.ORCID 0000-0002-5247-4633
Ryan P BellDepartment of Psychiatry & Behavioral Sciences, Duke University School of Medicine, Durham, NC, 27705, USA.ORCID 0000-0003-4689-9763
Julian BaptisteDiagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 670 W. Baltimore Street, HSF III, Room 1161, Baltimore, MD, 21201, USA.
Linda ChangDiagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 670 W. Baltimore Street, HSF III, Room 1161, Baltimore, MD, 21201, USA. lchang@som.umaryland.edu.ORCID 0000-0002-1267-0699

Funding

Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
Role of cannabis on HIV-related cognitive impairment: a brain connectomics studyR01DA047149 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MEADE, CHRISTINA S · 2018 to 2023
$3.1M
Neural Correlates of Working Memory Training For HIV PatientsR01DA035659 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI CHANG, LINDA · 2012 to 2017
$2.8M
MRI data fusion to investigate effects of drug abuse on HIV neurological complicationsR01DA045565 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MEADE, CHRISTINA S · 2018 to 2022
$2.0M
NIAID NIH HHS P30 AI064518NIDA NIH HHS R01 DA035659NIDA NIH HHS R01-DA 035659NIDA NIH HHS R01 DA045565NIDA NIH HHS R01-DA045565NIDA NIH HHS R01 DA047149
6 · The paper itself

Abstract

Globally, cannabis is the most commonly used illicit drug, with disproportionately high use among persons with HIV. Despite advances in HIV care, nearly half of persons living with HIV continue to experience neurocognitive deficits or impairments that may have negative impacts on their daily function. Chronic cannabis use may play a role in the development or exacerbation of these impairments. Here we present a review summarizing existing research detailing the effect of cannabis use associated with the neuropathogenesis of HIV. We examine evidence for possible additive or synergistic effects of HIV infection and cannabis use on neuroHIV in both the preclinical and adult human literatures, including in vitro studies, animal models, clinical neuroimaging research, and studies examining the cognitive effects of cannabis. We discuss the limitations of existing research, including methodological challenges involved with clinical research with human subjects. We identify gaps in the field and propose critical research questions to advance our understanding of how cannabis use affects neuroHIV. Graphical Abstract.

Indexed as

Marijuana UseAnimalsBrainCannabinoidsCognitionHIV InfectionsHumansCannabinoidsCannabisEndocannabinoid systemHIVNeuropathogenesis

Identifiers

PMID32445005
PMCPMC7680275

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.