Evidence map›Paper›PMID 32445000›Full record

ArticleApplied microbiology and biotechnology2020

Fine mapping of linear B cell epitopes on capsid protein of porcine circovirus 3.

Min Jiang, Junqing Guo, Gaiping Zhang, Qianyue Jin, Yankai Liu, Rui Jia, Aiping Wang

Abstract read
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In one paragraph

Article in Applied microbiology and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Min JiangSchool of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Junqing GuoKey Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, 450002, China.
Gaiping ZhangSchool of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Qianyue JinKey Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, 450002, China.
Yankai LiuSchool of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Rui JiaSchool of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Aiping WangSchool of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China. pingaw@126.com.
Zhengzhou University · CNHenan Academy of Agricultural Sciences · CN

Funding

National Key Research and Development Program of China 2016YFD0500704
6 · The paper itself

Abstract

Porcine circovirus type 3 (PCV3) is an emerging swine pathogen associated with acute porcine dermatitis and nephropathy syndrome (PDNS)-like clinical signs, reproductive failure, and multisystemic inflammation. Current evidence shows that PCV3 is spread worldwide, and its high incidence may pose a threat to the global pig industry. Capsid (Cap) protein is the sole structural protein which plays an important role in inducing protective immunity against PCV3 infection. In this study, monoclonal antibodies (mAbs) against Cap protein of PCV3 were produced by the hybridoma technique. Subsequently, 12 serial overlapping peptides (P1 to P12) spanning the entire region of Cap were synthesized to determine the B cell epitope regions using the mAbs. Results from dot-blot and peptide ELISA identified that P3, P9, and P10 were the major B cell antigenic regions. Fine mapping by shorter N- and C-terminal truncated peptides confirmed that the motifs

Indexed as

Amino Acid MotifsAnimalsAntibodies, MonoclonalCapsid ProteinsCell LineCircoviridae InfectionsCircovirusEpitope MappingEpitopes, B-LymphocyteHumansMiceModels, MolecularRecombinant ProteinsSwineSwine DiseasesAntibodies, MonoclonalCapsid ProteinsEpitopes, B-LymphocyteRecombinant ProteinsCapsid proteinEpitopeMonoclonal antibodiesPorcine circovirus 3

Identifiers

PMID32445000
OpenAlexW3026399207

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.