Evidence map›Paper›PMID 32444975›Full record

ArticleMolecular biology reports2020

Plumbagin promotes mitochondrial mediated apoptosis in gefitinib sensitive and resistant A549 lung cancer cell line through enhancing reactive oxygen species generation.

Munmun Panda, Surya Kant Tripathi, Bijesh K Biswal

Abstract read
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In one paragraph

Article in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Munmun PandaCancer Drug Resistance Laboratory, Department of Life, Science, National Institute of Technology, Rourkela, Odisha, 769008, India.
Surya Kant TripathiCancer Drug Resistance Laboratory, Department of Life, Science, National Institute of Technology, Rourkela, Odisha, 769008, India.
Bijesh K BiswalCancer Drug Resistance Laboratory, Department of Life, Science, National Institute of Technology, Rourkela, Odisha, 769008, India. biswalb@nitrkl.ac.in.ORCID http://orcid.org/0000-0002-5609-7660
National Institute of Technology Rourkela · IN

Funding

Department of Science and Technology, Odisha, India 1201Department of Science and technology, Science and Engineering Research Board (DST, SERB), New Delhi, India ECR/2016/000792
6 · The paper itself

Abstract

Plumbagin (PL) is a natural naphthoquinone compound, isolated from Plumbago zeylanica that has cytotoxic and antimigratory potential in many cancer. However, the cytotoxic mechanism of plumbagin in drug resistant lung cancer is poorly understood. To reveal the mechanism, we studied the anticancer effect of plumbagin in both gefitinib-sensitive and resistant A549 lung cancer cells. The anticancer potential of PL was demonstrated by MTT assay and the result suggested that PL showed cytotoxicity in both gefitinib-sensitive (A549) and gefitinib-resistant (A549GR) lung cancer cells. IC

Indexed as

A549 CellsApoptosisCell CycleCell Cycle CheckpointsCell ProliferationCell SurvivalGefitinibHumansLung NeoplasmsMembrane Potential, MitochondrialMitochondriaNaphthoquinonesReactive Oxygen SpeciesGefitinibNaphthoquinonesplumbaginReactive Oxygen SpeciesApoptosisDrug resistanceLung cancerMitochondrial membrane potentialPlumbaginReactive oxygen species

Identifiers

PMID32444975
OpenAlexW3026716148

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.