ArticleActa neurologica Belgica2021
Are patients with Down syndrome vulnerable to life-threatening COVID-19?
Article in Acta neurologica Belgica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- COVID-19 in patients with Down syndrome: A systematic review.Immunity, inflammation and disease · 2024Pooled it
- Tailored vs. General COVID-19 prevention for adults with mental disabilities residing in group homes: a randomized controlled effectiveness-implementation trial.BMC public health · 2024Trial
- Enhancing understanding of SARS-CoV-2 infection among individuals with Down syndrome: An integrative review.Sao Paulo medical journal = Revista paulista de medicina · 2023Review
- Risk for Severe Illness and Death among Pediatric Patients with Down Syndrome Hospitalized for COVID-19, Brazil.Emerging infectious diseases · 2023Article
- COVID-19 hospitalization with later long COVID in a person with Down syndrome.Clinical case reports · 2022Article
- Impact of the COVID-19 pandemic on daily life, mood, and behavior of adults with Down syndrome.Disability and health journal · 2022Article
- 'Now that I am connected this isn't social isolation, this is engaging with people': Staying connected during the COVID-19 pandemic.British journal of learning disabilities · 2022Article
- Adapted remote cognitive behavioural therapy for comfort eating with a woman with intellectual disabilities: Case report.Journal of eating disorders · 2022Article
- Aging with Down Syndrome-Where Are We Now and Where Are We Going?Journal of clinical medicine · 2021Review
- Article
- Comparison of COVID-19 and Non-COVID-19 Pneumonia in Down Syndrome.Journal of clinical medicine · 2021Article
- Health Risks and Consequences of a COVID-19 Infection for People with Disabilities: Scoping Review and Descriptive Thematic Analysis.International journal of environmental research and public health · 2021Article
- Medical vulnerability of individuals with Down syndrome to severe COVID-19-data from the Trisomy 21 Research Society and the UK ISARIC4C survey.EClinicalMedicine · 2021Article
- Supports for people with intellectual and developmental disabilities during the COVID-19 pandemic from their own perspective.Research in developmental disabilities · 2021Article
- COVID-19 and children with Down syndrome: is there any real reason to worry? Two case reports with severe course.BMC pediatrics · 2020Article
- JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome.Cell reports · 2020Article
- The SARS-CoV-2 receptor, ACE-2, is expressed on many different cell types: implications for ACE-inhibitor- and angiotensin II receptor blocker-based cardiovascular therapies: comment.Internal and emergency medicine · 2020Article
- COVID-19, Acute Lymphoblastic Leukemia, and Down Syndrome: A Short Review and a Case Report.Case reports in oncologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with Down syndrome are at increased risk of respiratory syncytial virus- and H1N1-related death. Literature on COVID-19 in Down syndrome patients is unavailable thus far. We describe the clinical course of 4 patients with Down syndrome during an outbreak of COVID-19. In all four patients, disease course was severe, warranting hospital care in three patients, with fatal outcome in one patient. Another patient receives supportive care in our institution. Our case series is the first report on probable increased risk of life-threatening disease course of COVID-19 in patients with Down syndrome. Proper surveillance, the adherence of social distancing, and the use of personal protective equipment will be essential in reducing morbidity and mortality in our patients.
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Registered trials
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