ArticleClinical oral investigations2020
Macrophages skew towards M1 profile through reduced CD163 expression in symptomatic apical periodontitis.
Article in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- Four-Octyl Itaconate Alleviates Enterococcus faecalis-Induced Apical Periodontitis by Inhibiting Macrophage M1 Polarisation.International endodontic journal · 2026Article
- Increased TET3 expression associates with proinflammatory cytokines and reduced 5-hydroxymethylcytosine in periapical lesions.Clinical oral investigations · 2026Article
- Immunotherapies based on macrophage reprogramming in periodontitis and apical periodontitis.Clinical oral investigations · 2026Review
- Immune Responses in Orthodontic Treatment.Advances in experimental medicine and biology · 2026Review
- Effect of membrane vesicles produced under different pH conditions on the ability ofJournal of bacteriology · 2025Article
- Exploring the regulatory roles of MicroRNAs on NF- ΚB target genes in individuals with apical periodontitis.Clinical oral investigations · 2025Article
- Metabolic syndrome and its effect on immune cells in apical periodontitis- a narrative review.Clinical oral investigations · 2025Review
- M1 and M2 macrophages markers are alternately expressed during periapical lesion development.Journal of applied oral science : revista FOB · 2025Article
- Identification of JNK-JUN-NCOA axis as a therapeutic target for macrophage ferroptosis in chronic apical periodontitis.International journal of medical sciences · 2025Article
- Article
- Milk-Derived Small Extracellular Vesicles Promote Osteogenic Differentiation and Inhibit Inflammation via microRNA-21.International journal of molecular sciences · 2023Article
- 3D Organoids for Regenerative Endodontics.Biomolecules · 2023Review
- [Akt2 inhibitor promotes M2 macrophage polarization in rats with periapical inflammation by reducing miR-155-5p expression].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Next-generation biomaterials for dental pulp tissue immunomodulation.Dental materials : official publication of the Academy of Dental Materials · 2023Review
- Role ofJournal of oral microbiology · 2023Review
- Tumor-derived Cav-1 promotes pre-metastatic niche formation and lung metastasis in breast cancer.Theranostics · 2023Article
- Tissue Levels of CD80, CD163 and CD206 and Their Ratios in Periodontal and Peri-Implant Health and Disease.Current issues in molecular biology · 2022Article
- Article
- Lipopolysaccharide fromInternational journal of molecular sciences · 2022Article
- Exosomes derived from M2 type tumor-associated macrophages promote osimertinib resistance in non-small cell lung cancer through MSTRG.292666.16-miR-6836-5p-MAPK8IP3 axis.Cancer cell international · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo explore the macrophage profiles in symptomatic and asymptomatic forms of AP through phenotypic and functional analyses. MATERIAL AND
methodsCross-sectional study. Apical tissue/lesion samples were collected from patients with clinical diagnosis of AAP (n = 51) or SAP (n = 45) and healthy periodontal ligament (HPL) from healthy patients as controls (n = 14), all with indication of tooth extraction. Samples were digested, cells were stained for CD14, M1 (CD64, CD80), and M2 (CD163, CD206) phenotypic surface markers and analyzed by flow cytometry. Functional cytokine profiles L-6, IL-12, TNF-α, IL-23 (M1), IL-10, and TGF-β (M2) were determined by qPCR.
resultsHigher macrophage M1/M2 ratio (CD64
conclusionsMacrophages exhibited a polarization switch towards M1 in AL. SAP exhibited a reduced M2 differentiation profile based on a reduction of CD163 expression levels in SAP over AAP. Specifically, IL-6 and IL-23 were augmented SAP over AAP, suggesting a role in the severity of apical lesions. CLINICAL RELEVANCE: Deciphering the macrophage polarization and functions in apical periodontitis can contribute to explain AP dynamics, its clinical presentation and systemic impact.
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