ArticleMolecular psychiatry2021
Linked patterns of biological and environmental covariation with brain structure in adolescence: a population-based longitudinal study.
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Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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33citing papers in PubMed, 2 pooled it
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impact of prenatal tobacco exposure on brain structure and function in offspring: a systematic review and meta-analysis of MRI findings.Neuroradiology · 2025Pooled it
- Multivariate brain-behaviour associations in psychiatric disorders.Translational psychiatry · 2024Pooled it
- Effects of adverse childhood experiences on behavior in adolescence: Insights from brain imaging and genetic risk.Developmental cognitive neuroscience · 2026Article
- Domain-general and language-specific brain networks are differentially associated with verbal intelligence during development.iScience · 2026Article
- Multiscale brain development across the human lifespan.Communications biology · 2026Review
- Aberrant multivariate mapping between behavioral profiles and cortical morphological brain networks in children with autism spectrum disorder.Translational psychiatry · 2026Article
- Utilizing multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with substance use disorders.Molecular psychiatry · 2026Article
- Subtypes of adolescent major depressive disorder characterized by divergent information dynamics in sensory-association cortices.Nature communications · 2026Article
- Using multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with cognitive performance.Translational psychiatry · 2026Article
- Independent brain cortical signatures of risk for adolescent cannabis use and consequences of such use are moderated by sex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Cortical Structure in Nodes of the Default Mode Network Estimates General Intelligence.Brain and behavior · 2025Article
- Dev-Atlas: A reference atlas of functional brain networks for typically developing adolescents.Developmental cognitive neuroscience · 2025Article
- Environmentally derived subgroups of preadolescents with family history of substance use exhibit distinct patterns of psychopathology and reward-related behaviors: insights from the ABCD study.Frontiers in child and adolescent psychiatry · 2025Article
- Prenatal Tobacco Exposure, Brain Subcortical Volumes, and Gray-White Matter Contrast.JAMA network open · 2024Article
- Linked patterns of symptoms and cognitive covariation with functional brain controllability in major depressive disorder.EBioMedicine · 2024Article
- Multivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2024Article
- A Shared Multivariate Brain-Behavior Relationship in a Transdiagnostic Sample of Adolescents.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Neural correlates of negative life events and their relationships with alcohol and cannabis use initiation.Dialogues in clinical neuroscience · 2023Article
- Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits.Molecular psychiatry · 2023Article
- Effects of urban living environments on mental health in adults.Nature medicine · 2023Article
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Authors and funding
37 authors.
Amirhossein ModabberniaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Abraham ReichenbergDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Alex IngPopulation Neuroscience and Precision Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Dominik A MoserDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gaelle E DoucetDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-4120-0474
Eric ArtigesInstitut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Saclay, University Paris Descartes - Sorbonne Paris Cité, Paris, France.ORCID http://orcid.org/0000-0003-4461-7646
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany.ORCID http://orcid.org/0000-0003-4595-1144
Gareth J BarkerDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-5214-7421
Andreas BeckerDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center, Göttingen, Germany.
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Erin Burke QuinlanCentre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, UK.ORCID http://orcid.org/0000-0003-2927-1632
Sylvane DesrivièresCentre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, UK.ORCID http://orcid.org/0000-0002-9120-7060
Herta FlorInstitute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.
Juliane H FröhnerDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0002-8493-6396
Hugh GaravanDepartments of Psychiatry and Psychology, University of Vermont, Burlington, VT, 05405, USA.
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK.
Antoine GrigisNeuroSpin, CEA, Université Paris-Saclay, 91191, Gif-sur-Yvette, France.
Yvonne GrimmerDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany.
Andreas HeinzDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Corinna InsenseeDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center, Göttingen, Germany.
Bernd IttermannPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig/Berlin, Germany.
Jean-Luc MartinotInstitut National de la Santé et de la Recherche INSERM Unit 1000 "Neuroimaging & Paris Saclay, University Paris Descartes and Maison de Solenn, Paris, France.ORCID http://orcid.org/0000-0002-0136-0388
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sacaly, University Paris Descartes, Paris, France.
Sabina MillenetDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany.
Frauke NeesDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany.
Dimitri Papadopoulos OrfanosNeuroSpin, CEA, Université Paris-Saclay, 91191, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0002-1242-8990
Tomáš PausBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital and Departments of Psychology and Psychiatry, University of Toronto, Toronto, ON, M6A 2E1, Canada.
Jani PenttiläDepartment of Social and Health Care, Psychosocial Services Adolescent Outpatient Clinic Kauppakatu 14, Lahti, Finland.ORCID http://orcid.org/0000-0001-6499-9376
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Str., 537075, Göttingen, Germany.
Michael N SmolkaDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0001-5398-5569
Argyris StringarisNational Institute of Mental Health/NIH, 15K North Drive, Bethesda, MD, 20892, USA.
Betteke M van NoortMSB Medical School Berlin, Hochschule für Gesundheit und Medizin, Siemens Villa, Berlin, Germany.ORCID http://orcid.org/0000-0002-9768-3383
Henrik WalterDepartment of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID http://orcid.org/0000-0002-9403-6121
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-2790-7281
Gunter SchumannCentre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King's College London, London, UK.ORCID http://orcid.org/0000-0002-7740-6469
Sophia FrangouDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. sophia.frangou@mssm.edu.
IMAGEN Consortium
Funding
Mood, Brain, and Development UnitZIAMH002957 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI STRINGARIS, ARGYRIOS · 2017 to 2022
$14.8MTraining U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MBrain connectivity and the role of myelin in PsychosisR01MH113619 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FRANGOU, SOPHIA · 2018 to 2021
$2.5MENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMAR01MH116147 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2021
$2.5MAxon, Testosterone and Mental Health during AdolescenceR01MH085772 · NIMH · BAYCREST CENTRE FOR GERIATRIC CARE · PI PAUS, TOMAS · 2010 to 2014
$1.5MENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683kDepartment of HealthMedical Research Council MR/N000390/1Medical Research Council MR/N027558/1Medical Research Council MR/R00465X/1Medical Research Council MR/S020306/1MRF_ MRF-058-0004-RG-DESRIMRF_ MRF-058-0009-RG-DESR-C0759NIA NIH HHS R56 AG058854NIBIB NIH HHS U54 EB020403NIMH NIH HHS R01 MH085772NIMH NIH HHS R01 MH113619NIMH NIH HHS R01 MH116147
Abstract
Adolescence is a period of major brain reorganization shaped by biologically timed and by environmental factors. We sought to discover linked patterns of covariation between brain structural development and a wide array of these factors by leveraging data from the IMAGEN study, a longitudinal population-based cohort of adolescents. Brain structural measures and a comprehensive array of non-imaging features (relating to demographic, anthropometric, and psychosocial characteristics) were available on 1476 IMAGEN participants aged 14 years and from a subsample reassessed at age 19 years (n = 714). We applied sparse canonical correlation analyses (sCCA) to the cross-sectional and longitudinal data to extract modes with maximum covariation between neuroimaging and non-imaging measures. Separate sCCAs for cortical thickness, cortical surface area and subcortical volumes confirmed that each imaging phenotype was correlated with non-imaging features (sCCA r range: 0.30-0.65, all P
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Canonical Correlation AnalysisMagnetic Resonance ImagingAdolescentAdultBrainCross-Sectional StudiesHumansLongitudinal StudiesYoung Adult
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