Evidence map›Paper›PMID 32444692›Full record

ReviewNature reviews. Cardiology2020

Cardiac natriuretic peptides.

Jens P Goetze, Benoit G Bruneau, Hugo R Ramos, Tsuneo Ogawa, Mercedes Kuroski de Bold, Adolfo J de Bold

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 321 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
321citing papers in PubMed, 4 pooled it
41.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

321 citing papers in PubMed, 4 syntheses or guidelines pooled it, 500 citations in OpenAlex.

  1. Pooled it
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  4. Pooled it
  5. Trial
  6. Review
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  16. Article
  17. Natriuretic Peptides as a Biomarker of Cognitive Decline in Hypertension.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
    Review
  18. Article
  19. Review
  20. Rare TruncatingGenes · 2026
    Article

261 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 5 countries.

Jens P GoetzeDepartment of Clinical Biochemistry, Rigshospitalet University Hospital, Copenhagen, Denmark.
Benoit G BruneauGladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-0804-7597
Hugo R RamosDivision of Cardiology, Instituto Modelo de Cardiología, Córdoba, Argentina.ORCID http://orcid.org/0000-0001-6772-903X
Tsuneo OgawaDepartment of Nutrition Management, Minami Kyushu University, Miyazaki, Japan.
Mercedes Kuroski de BoldDepartment of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.ORCID http://orcid.org/0000-0003-1529-0285
Adolfo J de BoldDepartment of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. adebold@bell.net.ORCID http://orcid.org/0000-0001-8655-4976
University of Ottawa · CAGladstone Institutes · USMinami Kyushu University · JPRigshospitalet · DKUniversidad Nacional de Córdoba · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Investigations into the mixed muscle-secretory phenotype of cardiomyocytes from the atrial appendages of the heart led to the discovery that these cells produce, in a regulated manner, two polypeptide hormones - the natriuretic peptides - referred to as atrial natriuretic factor or atrial natriuretic peptide (ANP) and brain or B-type natriuretic peptide (BNP), thereby demonstrating an endocrine function for the heart. Studies on the gene encoding ANP (NPPA) initiated the field of modern research into gene regulation in the cardiovascular system. Additionally, ANP and BNP were found to be the natural ligands for cell membrane-bound guanylyl cyclase receptors that mediate the effects of natriuretic peptides through the generation of intracellular cGMP, which interacts with specific enzymes and ion channels. Natriuretic peptides have many physiological actions and participate in numerous pathophysiological processes. Important clinical entities associated with natriuretic peptide research include heart failure, obesity and systemic hypertension. Plasma levels of natriuretic peptides have proven to be powerful diagnostic and prognostic biomarkers of heart disease. Development of pharmacological agents that are based on natriuretic peptides is an area of active research, with vast potential benefits for the treatment of cardiovascular disease.

Indexed as

AnimalsAtrial AppendageAtrial FibrillationAtrial Natriuretic FactorAtrial RemodelingBiomarkersCyclic GMPDiabetes MellitusFibrosisGene Expression Regulation, DevelopmentalHeart AtriaHeart FailureHumansHypertensionLipid MetabolismMetabolic SyndromeAtrial Natriuretic FactorBiomarkersCyclic GMPmidregional pro-atrial natriuretic peptide, humanNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Receptors, Guanylate Cyclase-Coupled

Identifiers

PMID32444692
OpenAlexW3027216380

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.