Evidence map›Paper›PMID 32444677›Full record

ArticleScientific reports2020

Relationship between headaches and tinnitus in a Swedish study.

Alessandra Lugo, Niklas K Edvall, Andra Lazar, Golbarg Mehraei, Jose-Antonio Lopez-Escamez, Jan Bulla, Inger Uhlen, Barbara Canlon, Silvano Gallus, Christopher R Cederroth

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Screening for Circulating Inflammatory Proteins Does Not Reveal Plasma Biomarkers of Constant Tinnitus.Journal of the Association for Research in Otolaryngology : JARO · 2023
    Pooled it
  2. Low Evidence for Tinnitus Risk Factors: A Systematic Review and Meta-analysis.Journal of the Association for Research in Otolaryngology : JARO · 2023
    Pooled it
  3. Article
  4. Tinnitus.Nature reviews. Disease primers · 2026
    Review
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  6. Article
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  8. Article
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  12. Review
  13. Article
  14. Association between Hyperacusis and Tinnitus.Journal of clinical medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 6 countries.

Alessandra Lugo *Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Niklas K Edvall *Laboratory of Experimental Audiology, Department of Physiology and Pharmacology, Karolinska Institutet, 171 77, Stockholm, Sweden.
Andra LazarHörsel och balansmottagningen, Karolinska Universitetssjukhuset, Stockholm, Sweden.
Golbarg MehraeiDecibel Therapeutics Inc., Boston, USA.
Jose-Antonio Lopez-EscamezOtology & Neurotology Group, Department of Genomic Medicine, Pfizer - Universidad de Granada - Junta de Andalucía Centro de Genómica e Investigación Oncológica (GENYO), PTS, Avenida de la Ilustración 114, 18016, Granada, Spain.
Jan BullaUniversity of Bergen, Bergen, Norway.
Inger UhlenHörsel och balansmottagningen, Karolinska Universitetssjukhuset, Stockholm, Sweden.
Barbara CanlonLaboratory of Experimental Audiology, Department of Physiology and Pharmacology, Karolinska Institutet, 171 77, Stockholm, Sweden.
Silvano GallusDepartment of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Christopher R CederrothLaboratory of Experimental Audiology, Department of Physiology and Pharmacology, Karolinska Institutet, 171 77, Stockholm, Sweden. christopher.cederroth@ki.se.
Karolinska Institutet · SEKarolinska University Hospital · SEMario Negri Institute for Pharmacological Research · ITDecImmune Therapeutics (United States) · USPfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research · ESUniversity of Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The heterogeneity of tinnitus is likely accounting for the lack of effective treatment approaches. Headaches have been related to tinnitus, yet little is known on how headaches impact tinnitus. We use cross-sectional data from the Swedish Tinnitus Outreach Project to i) evaluate the association between headaches and tinnitus (n = 1,984 cases and 1,661 controls) and ii) investigate the phenotypic characteristics of tinnitus subjects with tinnitus (n = 660) or without (n = 1,879) headaches. In a multivariable logistic regression model, headache was significantly associated with any tinnitus (odds ratio, OR = 2.61) and more so with tinnitus as a big problem (as measured by the tinnitus functional index, TFI ≥ 48; OR = 5.63) or severe tinnitus (using the tinnitus handicap inventory, THI ≥ 58; OR = 4.99). When focusing on subjects with tinnitus, the prevalence of headaches was 26% and reached 40% in subjects with severe tinnitus. A large number of socioeconomic, phenotypic and psychological characteristics differed between headache and non-headache subjects with any tinnitus. With increasing tinnitus severity, fewer differences were found, the major ones being vertigo, neck pain and other pain syndromes, as well as stress and anxiety. Our study suggests that headaches could contribute to tinnitus distress and potentially its severity.

Indexed as

Severity of Illness IndexAdultAgedAged, 80 and overAnxietyCase-Control StudiesCross-Sectional StudiesDepressionFemaleHeadacheHumansMaleMiddle AgedPrevalenceSurveys and QuestionnairesSweden

Identifiers

PMID32444677
PMCPMC7244494
OpenAlexW3026716733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.