ArticleNature communications2020
TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling.
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Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
–field-weighted citation impact
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Who cites it
18 citing papers in PubMed.
- Finerenone mitigates acute alcoholic myocardial injury by modulating inflammatory signaling, oxidative stress, and mitochondrial function.Molecular medicine (Cambridge, Mass.) · 2026Article
- The Thymus Regeneration Paradox: The Search for Stemness in an Involuting Organ.Immunological reviews · 2026Review
- Regulation of revival stem cell differentiation by CREPT/RPRD1B during intestinal regeneration.Cell & bioscience · 2025Article
- Chromatin remodelling in damaged intestinal crypts orchestrates redundant TGFβ and Hippo signalling to drive regeneration.Nature cell biology · 2024Article
- Pancreastatin Inhibition Alters the Colonic Epithelial Cells Profile in a Sex-Dependent Manner.International journal of molecular sciences · 2024Article
- The Role of the Gut Microbiome in the Development of Acute Pancreatitis.International journal of molecular sciences · 2024Review
- Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus.Developmental cell · 2023Article
- Article
- PTBP1 controls intestinal epithelial regeneration through post-transcriptional regulation of gene expression.Nucleic acids research · 2023Article
- Glutamine supplementation improves contractile function of regenerating soleus muscles from rats.Journal of muscle research and cell motility · 2022Article
- TIPE2 Promotes Tumor Initiation But Inhibits Tumor Progression in Murine Colitis-Associated Colon Cancer.Inflammatory bowel diseases · 2022Article
- TNFAIP8 protein functions as a tumor suppressor in inflammation-associated colorectal tumorigenesis.Cell death & disease · 2022Article
- Mechanisms modulating the activities of intestinal stem cells upon radiation or chemical agent exposure.Journal of radiation research · 2022Article
- The role of intestinal stem cell within gut homeostasis: Focusing on its interplay with gut microbiota and the regulating pathways.International journal of biological sciences · 2022Review
- Identification of immune infiltration and cuproptosis-related subgroups in Crohn's disease.Frontiers in immunology · 2022Article
- Article
- Article
- Subversion of Niche-Signalling Pathways in Colorectal Cancer: What Makes and Breaks the Intestinal Stem Cell.Cancers · 2021Review
Corrections and comments
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Authors and funding
19 authors.
Jason R GoldsmithDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. goldsj@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0003-2874-8013
Nina SpitofskyDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ali ZamaniDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ryan HoodDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Amanda BoggsDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Xinyuan LiDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Mingyue LiDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Elizabeth ReinerDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Arshad AyyazCentre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Zienab EtwebiDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ling LuDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Javier Rivera GuzmanDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Mayassa J Bou-DarghamDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0002-1551-8887
Terry CathoupolisDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Hakon HakonarsonCenter for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.ORCID http://orcid.org/0000-0003-2814-7461
Honghong SunDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Jeffrey L WranaCentre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Michael V GonzalezCenter for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.
Youhai H ChenDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. yhc@pennmedicine.upenn.edu.
Funding
TRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI REBECCA G WELLS · 1997 to 2026
$32.5MIMMUNOBIOLOGY OF NORMAL AND NEOPLASTIC LYMPHOCYTEST32CA009140 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Malay Haldar, WARREN S PEAR · 1985 to 2026
$16.1MHEMATOPOIESIS TRAINING GRANTT32DK007780 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI TONG, WEI · 1999 to 2023
$6.7MRegulating Leukocyte Migration in InflammationR01AI136945 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SUN, HONGHONG · 2018 to 2022
$2.0MThe role and mechanism of TNFAIP8 in intestinal inflammation and wound healingF32DK116528 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GOLDSMITH, JASON R. · 2018 to 2019
$135kNCI NIH HHS T32 CA009140NIAID NIH HHS R01 AI136945NIDDK NIH HHS F32 DK116528NIDDK NIH HHS P30 DK050306NIDDK NIH HHS T32 DK007780
Abstract
The intestine is a highly dynamic environment that requires tight control of the various inputs to maintain homeostasis and allow for proper responses to injury. It was recently found that the stem cell niche and epithelium is regenerated after injury by de-differentiated adult cells, through a process that gives rise to Sca1+ fetal-like cells and is driven by a transient population of Clu
Indexed as
AnimalsApoptosis Regulatory ProteinsAtaxin-1Cell DifferentiationColitisEnterocytesFemaleGastrointestinal MicrobiomeGene Knockdown TechniquesHomeostasisIntestinesIschemiaLeukocyte Common AntigensMaleMice, Inbred C57BLProto-Oncogene Proteins c-aktApoptosis Regulatory ProteinsAtaxin-1Atxn1 protein, mouseLeukocyte Common AntigensProto-Oncogene Proteins c-aktPtprc protein, mouseTNFAIP8 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.