ArticleNature communications2020
Genome-scale metabolic reconstruction of the symbiosis between a leguminous plant and a nitrogen-fixing bacterium.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 92 citations in OpenAlex.
- A genome-scale metabolic model of a pathosystem sheds light on bacterial wilt.Plant physiology · 2026Article
- Mitochondrial glutamine synthetase overexpression in tomato source leaves increases assimilate export and fruit yield.The Plant cell · 2026Article
- Deciphering the genetic basis of nodule number through integrative analysis of host genotype and endophytes.Journal of advanced research · 2026Article
- Metabolic modeling predicts synergistic growth benefits between arbuscular mycorrhizal fungi and theoretical N2-fixing rhizobia symbiosis in maize.Plant physiology · 2026Article
- Predictive multispecies constraint-based metabolic modeling: case studies and best practices.Briefings in bioinformatics · 2026Review
- Synthetic Biology of Plants and Microbes for Agriculture, Environment, and Future Applications.Chemical reviews · 2026Review
- A voyage of reprogrammable metabolic bioengineering reshapes plant defense: from editing tools to synthetic systems.Frontiers in plant science · 2026Review
- Polyhydroxyalkanoate synthesis by Sinorhizobium meliloti drives a host-specific collapse in symbiosis with Medicago sativa.Research square · 2025Article
- Mobile gene clusters and coexpressed plant-rhizobium pathways drive partner quality variation in symbiosis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Nitrogen fertilization nullifies host sanctions against non-fixing rhizobia and drives divestment from symbiosis inProceedings. Biological sciences · 2025Article
- New insights in metabolism modelling to decipher plant-microbe interactions.The New phytologist · 2025Review
- In silico encounters: harnessing metabolic modelling to understand plant-microbe interactions.FEMS microbiology reviews · 2025Review
- Engineering plant holobionts for climate-resilient agriculture.The ISME journal · 2025Review
- Mechanisms of cooperation in the plants-arbuscular mycorrhizal fungi-bacteria continuum.The ISME journal · 2025Review
- Metabolic modeling of host-microbe interactions.Computational and structural biotechnology journal · 2025Review
- Genome-scale metabolic modelling reveals interactions and key roles of symbiont clades in a sponge holobiont.Nature communications · 2024Article
- Drought-Adapted Mediterranean Diet Plants: A Source of Bioactive Molecules Able to Give Nutrigenomic Effects per sè or to Obtain Functional Foods.International journal of molecular sciences · 2024Review
- Designing a synthetic microbial community through genome metabolic modeling to enhance plant-microbe interaction.Environmental microbiome · 2023Article
- Global Map of Specialized Metabolites Encoded in Prokaryotic Plasmids.Microbiology spectrum · 2023Article
- Towards applications of genome-scale metabolic model-based approaches in designing synthetic microbial communities.Quantitative biology (Beijing, China) · 2023Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mutualistic association between leguminous plants and endosymbiotic rhizobial bacteria is a paradigmatic example of a symbiosis driven by metabolic exchanges. Here, we report the reconstruction and modelling of a genome-scale metabolic network of Medicago truncatula (plant) nodulated by Sinorhizobium meliloti (bacterium). The reconstructed nodule tissue contains five spatially distinct developmental zones and encompasses the metabolism of both the plant and the bacterium. Flux balance analysis (FBA) suggests that the metabolic costs associated with symbiotic nitrogen fixation are primarily related to supporting nitrogenase activity, and increasing N
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.