ArticleNature communications2020
A unified neurocognitive model of semantics language social behaviour and face recognition in semantic dementia.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 70 citations in OpenAlex.
- The orbitofrontal-anterior temporal network complements the attention network for where to look in social situations.eNeuro · 2026Article
- The presymptomatic and early manifestations of semantic dementia.Brain : a journal of neurology · 2026Article
- Atrophy progression in frontotemporal lobar degeneration-TDP-C with primary progressive aphasia.Brain : a journal of neurology · 2026Article
- The neural bases of frontotemporal dementia and primary progressive aphasia subtypes: insights from activation likelihood estimation meta-analyses of 8057 patients.Brain communications · 2026Review
- Understanding the mind-brain relationship through focal neurodegenerative pathology.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Behavioural changes in frontotemporal dementia and their cognitive and neuroanatomical correlates.Brain : a journal of neurology · 2025Article
- Validation of criteria for frontotemporal dementia with right anterior temporal lobe predominance.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Automated Speech Analysis to Differentiate Frontal and Right Anterior Temporal Lobe Atrophy in Frontotemporal Dementia.Neurology · 2025Article
- The 7 Muses of Neuro-Creative Cycle: How some patients with Parkinson's disease can unleash latent creativity.AIMS neuroscience · 2025Article
- Network changes associated with right anterior temporal lobe atrophy: insight into unique symptoms.Brain communications · 2025Article
- Perceptual and semantic deficits in face recognition in semantic dementia.Neuropsychologia · 2024Article
- Graded Multidimensional Clinical and Radiologic Variation in Patients With Alzheimer Disease and Posterior Cortical Atrophy.Neurology · 2024Observational
- The impact of bilateral versus unilateral anterior temporal lobe damage on face recognition, person knowledge and semantic memory.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- A neuroanatomical and cognitive model of impaired social behaviour in frontotemporal dementia.Brain : a journal of neurology · 2024Review
- Assessing processing speed and its neural correlates in the three variants of primary progressive aphasia with a non-verbal tablet-based task.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Social-semantic knowledge in frontotemporal dementia and after anterior temporal lobe resection.Brain communications · 2024Article
- The neural substrates of transdiagnostic cognitive-linguistic heterogeneity in primary progressive aphasia.Alzheimer's research & therapy · 2023Article
- The spatiotemporal dynamics of semantic integration in the human brain.Nature communications · 2023Article
- Neuropsychiatric symptoms and imbalance of atrophy in behavioral variant frontotemporal dementia.Human brain mapping · 2023Article
- Functional and structural network changes related with cognition in semantic dementia longitudinally.Human brain mapping · 2023Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 4 countries.
Funding
Abstract
The anterior temporal lobes (ATL) have become a key brain region of interest in cognitive neuroscience founded upon neuropsychological investigations of semantic dementia (SD). The purposes of this investigation are to generate a single unified model that captures the known cognitive-behavioural variations in SD and map these to the patients' distribution of frontotemporal atrophy. Here we show that the degree of generalised semantic impairment is related to the patients' total, bilateral ATL atrophy. Verbal production ability is related to total ATL atrophy as well as to the balance of left > right ATL atrophy. Apathy is found to relate positively to the degree of orbitofrontal atrophy. Disinhibition is related to right ATL and orbitofrontal atrophy, and face recognition to right ATL volumes. Rather than positing mutually-exclusive sub-categories, the data-driven model repositions semantics, language, social behaviour and face recognition into a continuous frontotemporal neurocognitive space.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.