ArticleThe Journal of biological chemistry2020
The transcription factor HAND2 up-regulates transcription of the
Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Membrane Progesterone Receptor Beta Regulates the Decidualization of Endometrial Stromal Cells in Women with Endometriosis.International journal of molecular sciences · 2025Article
- Altered Expressions ofJournal of clinical medicine · 2024Article
- Altered Expression ofDiagnostics (Basel, Switzerland) · 2024Article
- Progesterone inactivation in decidual stromal cells: A mechanism for inflammation-induced parturition.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- MiR-135a-5p regulates window of implantation by suppressing pinopodes development and decidualization of endometrial stromal cells.Journal of assisted reproduction and genetics · 2024Article
- An Estrogen-NK Cells Regulatory Axis in Endometriosis, Related Infertility, and Miscarriage.International journal of molecular sciences · 2024Review
- Exploring the role of exosomal MicroRNAs as potential biomarkers in preeclampsia.Frontiers in immunology · 2024Review
- A systematic review of transcriptomic studies of the human endometrium reveals inconsistently reported differentially expressed genes.Reproduction & fertility · 2023Article
- Progress on the Role of Estrogen and Progesterone Signaling in Mouse Embryo Implantation and Decidualization.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Regulation of HAND2 Expression by LncRNAJournal of the Endocrine Society · 2023Article
- Ovarian Stimulation in Mice Resulted in Abnormal Placentation through Its Effects on Proliferation and Cytokine Production of Uterine NK Cells.International journal of molecular sciences · 2023Article
- The NR2F2-HAND2 signaling axis regulates progesterone actions in the uterus at early pregnancy.Frontiers in endocrinology · 2023Article
- Immune Tolerance of Embryo Implantation and Pregnancy: The Role of Human Decidual Stromal Cell- and Embryonic-Derived Extracellular Vesicles.International journal of molecular sciences · 2022Review
- The Regulators of Human Endometrial Stromal Cell Decidualization.Biomolecules · 2022Review
- The Estrogen Receptor α Cistrome in Human Endometrium and Epithelial Organoids.Endocrinology · 2022Article
- BHLHE22 Expression Is Associated with a Proinflammatory Immune Microenvironment and Confers a Favorable Prognosis in Endometrial Cancer.International journal of molecular sciences · 2022Article
- Characterization of Epigenetic and Molecular Factors in Endometrium of Females with Infertility.Biomedicines · 2022Article
- MAX deficiency impairs human endometrial decidualization through down-regulating OSR2 in women with recurrent spontaneous abortion.Cell and tissue research · 2022Article
- Shp2 in uterine stromal cells critically regulates on time embryo implantation and stromal decidualization by multiple pathways during early pregnancy.PLoS genetics · 2022Article
- Decidualization of human endometrial stromal cells requires steroid receptor coactivator-3.Frontiers in reproductive health · 2022Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclic changes of the human endometrium, such as proliferation, secretion, and decidualization, occur during regular menstrual cycles. Heart- and neural crest derivatives-expressed transcript 2 (HAND2) is a key transcription factor in progestin-induced decidualization of human endometrial stromal cells (ESCs). It has been suggested that HAND2 regulates interleukin 15 (IL15), a key immune factor required for the activation and survival of uterine natural killer (uNK) cells. Activated uNK cells can promote spiral artery remodeling and secrete cytokines to induce immunotolerance. To date, no studies have evaluated the transcription factors that regulate
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.