Evidence map›Paper›PMID 32444466›Full record

ReviewCancer discovery2020

The Landscape of Human Cancer Proteins Targeted by SARS-CoV-2.

Beril Tutuncuoglu, Merve Cakir, Jyoti Batra, Mehdi Bouhaddou, Manon Eckhardt, David E Gordon, Nevan J Krogan

Open access · bronzeAbstract readReview
In one paragraph

Review in Cancer discovery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Investigating DNA damage caused by COVID-19 and influenza in post COVID-19.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. High Risk of Heart Tumors after COVID-19.Life (Basel, Switzerland) · 2023
    Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Cancer and Covid-19: Collectively catastrophic.Cytokine & growth factor reviews · 2022
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Beril TutuncuogluDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, California.ORCID https://orcid.org/0000-0002-5458-2988
Merve CakirDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, California.ORCID https://orcid.org/0000-0003-1803-5693
Jyoti BatraDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, California.
Mehdi BouhaddouDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, California.
Manon EckhardtDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, California.ORCID https://orcid.org/0000-0001-8143-6129
David E GordonDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, California.
Nevan J KroganDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, California. nevan.krogan@ucsf.edu.
QB3 · US

Funding

The role of Listeria cyclic-di-AMP during infection and immunityP01AI063302 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI COX, JEFFERY S · 2004 to 2025
$45.5M
SARS-CoV adaptations through a Systems Biology Lens (SYBIL)U19AI135972 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Adolfo Garcia-Sastre · 2018 to 2026
$27.2M
RESEARCH PROJECT 2U19AI135990 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nevan J Krogan · 2018 to 2026
$21.4M
X-ray Screening and Rapid Structure DeterminationP50AI150476 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EMERMAN, MICHAEL · 2019 to 2021
$14.4M
Using Networks to Seed Hierarchical Whole-cell Models of CancerU54CA209891 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI IDEKER, TREY · 2017 to 2021
$10.9M
Novel VP30-host Interactions that Negatively Regulate Ebola Virus InfectionR01AI143292 · NIAID · WASHINGTON UNIVERSITY · PI AMARASINGHE, GAYA K., BASLER, CHRISTOPHER F · 2019 to 2023
$4.0M
Discovery of novel, ubiquitin-regulated mechanisms of TB control by macrophagesR01AI120694 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COX, JEFFERY S, KROGAN, NEVAN J · 2015 to 2019
$3.3M
Decoding the Chlamydia inclusion membrane protein-host protein interactomeR01AI122747 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ENGEL, JOANNE N., KAAKE, ROBYN MIDORI · 2016 to 2020
$3.1M
Systematic Targeting of Oncogene Interacting Proteins to Reveal New Therapeutic StrategiesF32CA239333 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOUHADDOU, MEHDI · 2019 to 2021
$192k
Uncovering differential functions of novel BRCA1 complexesF32CA239336 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TUTUNCUOGLU, BERIL · 2019 to 2020
$111k
NCI NIH HHS F32 CA239333NCI NIH HHS F32 CA239336NCI NIH HHS U54 CA209891NIAID NIH HHS P01 AI063302NIAID NIH HHS P50 AI150476NIAID NIH HHS R01 AI120694NIAID NIH HHS R01 AI122747NIAID NIH HHS R01 AI143292NIAID NIH HHS U19 AI135972NIAID NIH HHS U19 AI135990
6 · The paper itself

Abstract

The mapping of SARS-CoV-2 human protein-protein interactions by Gordon and colleagues revealed druggable targets that are hijacked by the virus. Here, we highlight several oncogenic pathways identified at the host-virus interface of SARS-CoV-2 to enable cancer biologists to apply their knowledge for rapid drug repurposing to treat COVID-19, and help inform the response to potential long-term complications of the disease.

Indexed as

BetacoronavirusDrug RepositioningCell CycleCoronavirus InfectionsCOVID-19DNA DamageEpigenomicsHumansNeoplasm ProteinsNeoplasmsPandemicsPneumonia, ViralProtein BiosynthesisSARS-CoV-2Neoplasm Proteins

Identifiers

PMID32444466
PMCPMC7357668
OpenAlexW3027076786

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.