Evidence map›Paper›PMID 32444408›Full record

ArticleThe European respiratory journal2020

Bioengineered airway epithelial grafts with mucociliary function based on collagen IV- and laminin-containing extracellular matrix scaffolds.

Nick J I Hamilton, Dani Do Hyang Lee, Kate H C Gowers, Colin R Butler, Elizabeth F Maughan, Benjamin Jevans, Jessica C Orr, Conor J McCann, Alan J Burns, Sheila MacNeil and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European respiratory journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. Article
  7. A novelThe European respiratory journal · 2024
    Article
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  16. Article
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  18. Article
  19. Stem Cell-derived Respiratory Epithelial Cell Cultures as Human Disease Models.American journal of respiratory cell and molecular biology · 2021
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Nick J I HamiltonLungs for Living Research Centre, UCL Respiratory, University College London, London, UK nick.hamilton@ucl.ac.uk.ORCID 0000-0001-6251-9316
Dani Do Hyang LeeRespiratory, Critical Care and Anaesthesia, UCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0002-2695-5759
Kate H C GowersLungs for Living Research Centre, UCL Respiratory, University College London, London, UK.ORCID 0000-0002-3481-4016
Colin R ButlerLungs for Living Research Centre, UCL Respiratory, University College London, London, UK.ORCID 0000-0003-4192-0519
Elizabeth F MaughanLungs for Living Research Centre, UCL Respiratory, University College London, London, UK.ORCID 0000-0001-6899-7589
Benjamin JevansStem Cell and Regenerative Medicine, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK.
Jessica C OrrLungs for Living Research Centre, UCL Respiratory, University College London, London, UK.ORCID 0000-0001-5138-6212
Conor J McCannStem Cell and Regenerative Medicine, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0002-9324-5984
Alan J BurnsStem Cell and Regenerative Medicine, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0002-1725-1071
Sheila MacNeilDept of Materials and Science Engineering, The Kroto Research Institute, North Campus, University of Sheffield, Sheffield, UK.
Martin A BirchallUCL Ear Institute, The Royal National Throat Nose and Ear Hospital, London, UK.ORCID 0000-0002-9211-1722
Christopher O'CallaghanRespiratory, Critical Care and Anaesthesia, UCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0002-8633-2473
Robert E HyndsLungs for Living Research Centre, UCL Respiratory, University College London, London, UK.ORCID 0000-0002-2170-8791
Sam M JanesLungs for Living Research Centre, UCL Respiratory, University College London, London, UK.ORCID 0000-0002-6634-5939
University College London · GBGreat Ormond Street Hospital · GBRoyal National Throat Nose and Ear Hospital · GBUniversity of Sheffield · GB

Funding

Medical Research Council G1001539Medical Research Council G108/596Medical Research Council MR/K017047/1Medical Research Council MR/L002000/1Medical Research Council MR/R015635/1Wellcome Trust 209199/Z/17/ZWellcome Trust WT107963AIAWellcome Trust WT209199/Z/17
6 · The paper itself

Abstract

Current methods to replace damaged upper airway epithelium with exogenous cells are limited. Existing strategies use grafts that lack mucociliary function, leading to infection and the retention of secretions and keratin debris. Strategies that regenerate airway epithelium with mucociliary function are clearly desirable and would enable new treatments for complex airway disease.Here, we investigated the influence of the extracellular matrix (ECM) on airway epithelial cell adherence, proliferation and mucociliary function in the context of bioengineered mucosal grafts.

Indexed as

CollagenExtracellular MatrixLamininRespiratory MucosaTissue ScaffoldsAnimalsBronchiCells, CulturedEpithelial CellsHumansRabbitsCollagenLaminin

Identifiers

PMID32444408
PMCPMC7301290
OpenAlexW3026147475

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.