Evidence map›Paper›PMID 32444372›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2021

Targeted PET Imaging of Chemokine Receptor 2-Positive Monocytes and Macrophages in the Injured Heart.

Gyu Seong Heo, Geetika Bajpai, Wenjun Li, Hannah P Luehmann, Deborah H Sultan, Hao Dun, Florian Leuschner, Steven L Brody, Robert J Gropler, Daniel Kreisel and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
  2. PET Imaging in Pulmonary Hypertension.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  3. Immuno-positron emission tomography in cardiovascular disease: Advances, challenges, and opportunities.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2026
    Review
  4. Next-generation molecular imaging of cardiac fibrosis.The international journal of cardiovascular imaging · 2026
    Review
  5. Advances in GPCR-Targeted PET Radiotracer Patents (2020-2025).Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. From incidental positron emission uptake toFrontiers in cardiovascular medicine · 2026
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Tissue-resident CCR2Cell reports · 2025
    Article
  16. CD45-targeted PET enables the visualization of inflammatory conditions.American journal of nuclear medicine and molecular imaging · 2025
    Article
  17. Review
  18. Article
  19. Molecular imaging of macrophage composition and dynamics in MASLD.JHEP reports : innovation in hepatology · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Gyu Seong HeoDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Geetika BajpaiDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Wenjun LiDepartment of Surgery, Washington University School of Medicine, St. Louis, Missouri.
Hannah P LuehmannDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Deborah H SultanDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Hao DunDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Florian LeuschnerDepartment of Internal Medicine III, University of Heidelberg, Heidelberg, Germany.
Steven L BrodyDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Robert J GroplerDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Daniel KreiselDepartment of Surgery, Washington University School of Medicine, St. Louis, Missouri kreiseld@wustl.edu klavine@wustl.edu yongjianliu@wustl.edu.
Kory J LavineDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri kreiseld@wustl.edu klavine@wustl.edu yongjianliu@wustl.edu.
Yongjian LiuDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri kreiseld@wustl.edu klavine@wustl.edu yongjianliu@wustl.edu.
Washington University in St. Louis · USHeidelberg University · DE

Funding

The Role of Neutrophils in Regulating Lung Transplant ToleranceP01AI116501 · NIAID · WASHINGTON UNIVERSITY · PI Daniel Kreisel · 2015 to 2026
$19.4M
Training/DisseminationP41EB025815 · NIBIB · WASHINGTON UNIVERSITY · PI Buck E. Rogers · 2018 to 2026
$12.7M
THE ROLE OF ISCHEMIA REPERFUSION INJURY IN LUNG ALLOGRAFT REJECTIONR01HL094601 · NHLBI · WASHINGTON UNIVERSITY · PI Andrew Eric Gelman, Daniel Kreisel · 2009 to 2026
$6.9M
Targeted Molecular Probes for Atherosclerosis Imaging and TherapyR35HL145212 · NHLBI · WASHINGTON UNIVERSITY · PI LIU, YONGJIAN · 2019 to 2025
$5.1M
Molecular Imaging CCR2 Lung Inflammation and FibrosisR01HL151685 · NHLBI · WASHINGTON UNIVERSITY · PI BRODY, STEVEN · 2021 to 2025
$3.7M
PET IMAGING CCR2 IN LUNG INFLAMMATIONR01HL131908 · NHLBI · WASHINGTON UNIVERSITY · PI BRODY, STEVEN, LIU, YONGJIAN · 2016 to 2018
$2.0M
MACROPHAGE HETEROGENEITY IN HEART FAILURE PROGRESSION AND CARDIAC RECOVERYR01HL138466 · NHLBI · WASHINGTON UNIVERSITY · PI LAVINE, KORY J. · 2017 to 2021
$1.9M
MACROPHAGE ONTOGENY SHIFTS IN ISCHEMIC HEART DISEASER01HL139714 · NHLBI · WASHINGTON UNIVERSITY · PI LAVINE, KORY J. · 2018 to 2021
$1.5M
EMBRYONIC-DERIVED MACROPHAGES IN CORONARY DEVELOPMENT AND ADULT CORONARY GROWTHK08HL123519 · NHLBI · WASHINGTON UNIVERSITY · PI LAVINE, KORY J. · 2014 to 2018
$715k
NHLBI NIH HHS K08 HL123519NHLBI NIH HHS R01 HL094601NHLBI NIH HHS R01 HL131908NHLBI NIH HHS R01 HL138466NHLBI NIH HHS R01 HL139714NHLBI NIH HHS R01 HL151685NHLBI NIH HHS R35 HL145212NIAID NIH HHS P01 AI116501NIBIB NIH HHS P41 EB025815
6 · The paper itself

Abstract

Proinflammatory macrophages are important mediators of inflammation after myocardial infarction and of allograft injury after heart transplantation. The aim of this study was to image the recruitment of proinflammatory chemokine receptor 2-positive (CCR2+) cells in multiple heart injury models.

Indexed as

Positron-Emission TomographyAnimalsHeart InjuriesIsotope LabelingMiceMice, Inbred C57BLMonocytesPhenprocoumonReceptors, CCR2CCR2 protein, humanPhenprocoumonReceptors, CCR2C-C chemokine receptor type 2 (CCR2)heart injurymacrophagesmonocytesPET

Identifiers

PMID32444372
PMCPMC9364878
OpenAlexW3026142419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.