Evidence map›Paper›PMID 32444356›Full record

ArticleJournal of the American Society of Nephrology : JASN2020

Experimental Antiglomerular Basement Membrane GN Induced by a Peptide from

Qiu-Hua Gu, Megan Huynh, Yue Shi, Xiao-Yu Jia, Jie-Jian Luo, Tai-Jiao Jiang, Zhao Cui, Joshua D Ooi, A Richard Kitching, Ming-Hui Zhao

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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  7. Perspectives in membranous nephropathy.Cell and tissue research · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Qiu-Hua GuRenal Division, Peking University First Hospital, Beijing, PR China.
Megan HuynhCentre for Inflammatory Diseases, Department of Medicine, Monash University, Monash Medical Centre, Clayton, Victoria, Australia.ORCID 0000-0003-3388-313X
Yue ShiRenal Division, Peking University First Hospital, Beijing, PR China.
Xiao-Yu JiaRenal Division, Peking University First Hospital, Beijing, PR China.
Jie-Jian LuoKey Laboratory of Protein and Peptide Pharmaceuticals, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, PR China.
Tai-Jiao JiangKey Laboratory of Protein and Peptide Pharmaceuticals, National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, PR China.
Zhao CuiRenal Division, Peking University First Hospital, Beijing, PR China cuizhao@bjmu.edu.cn.
Joshua D OoiCentre for Inflammatory Diseases, Department of Medicine, Monash University, Monash Medical Centre, Clayton, Victoria, Australia.
A Richard KitchingCentre for Inflammatory Diseases, Department of Medicine, Monash University, Monash Medical Centre, Clayton, Victoria, Australia.ORCID 0000-0002-2713-2391
Ming-Hui ZhaoRenal Division, Peking University First Hospital, Beijing, PR China.ORCID 0000-0003-3340-3108
Ministry of Education of the People's Republic of China · CNMonash Medical Centre · AUChinese Academy of Sciences · CNKing University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntiglomerular basement membrane (anti-GBM) disease is associated with HLA-DRB1*1501 (the major predisposing genetic factor in the disease), with

methodsTo investigate whether microbes might activate autoreactive T and B lymphocytes

resultsOn the basis of the critical motif, the bioinformatic approach identified 36 microbial peptides that mimic human

conclusionsSera from patients with anti-GBM disease recognized microbial peptides identified through a bioinformatic approach, and a peptide from

Indexed as

ActinomycesAnimalsAnti-Glomerular Basement Membrane DiseaseB7 AntigensBacterial ProteinsCollagen Type IVHLA-DR Serological SubtypesHumansLymphocyte ActivationMicePeptidesRatsRats, Inbred WKYT-LymphocytesB7 AntigensBacterial ProteinsCollagen Type IVHLA-DR15 antigenHLA-DR Serological SubtypesPeptidesglomerular diseasepathologyrenal injury

Identifiers

PMID32444356
PMCPMC7269348
OpenAlexW3028046744

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.