Evidence map›Paper›PMID 32444269›Full record

ReviewThe Lancet. Respiratory medicine2020

Immunotherapies for COVID-19: lessons learned from sepsis.

Kenneth E Remy, Scott C Brakenridge, Bruno Francois, Thomas Daix, Clifford S Deutschman, Guillaume Monneret, Robin Jeannet, Pierre-Francois Laterre, Richard S Hotchkiss, Lyle L Moldawer

Open access · bronzeAbstract readReview
In one paragraph

Review in The Lancet. Respiratory medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 1 synthesis or guideline pooled it, 165 citations in OpenAlex.

  1. Cardiorenal Syndrome in COVID-19 Patients: A Systematic Review.Frontiers in cardiovascular medicine · 2022
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The Impact of Pathogens on Sepsis Prevalence and Outcome.Pathogens (Basel, Switzerland) · 2024
    Review
  9. Article
  10. Observational
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 3 countries.

Kenneth E RemyDepartments of Pediatrics and Internal Medicine, Washington University School of Medicine, St Louis, MO, USA.
Scott C BrakenridgeDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL 32610-0108, USA.
Bruno FrancoisINSERM CIC-1435, Dupuytren University Hospital, Limoges, France; Intensive Care Unit, Dupuytren University Hospital, Limoges, France; INSERM UMR-1092, Université Limoges, Limoges, France.
Thomas DaixINSERM CIC-1435, Dupuytren University Hospital, Limoges, France; Intensive Care Unit, Dupuytren University Hospital, Limoges, France; INSERM UMR-1092, Université Limoges, Limoges, France.
Clifford S DeutschmanCohen Children's Medical Center, Northwell Health, Feinstein Institute for Medical Research, Zucker-Hofstra School of Medicine, Manhasset, NY, USA.
Guillaume MonneretCellular Immunology Laboratory, Hospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France.
Robin JeannetINSERM CIC-1435, Dupuytren University Hospital, Limoges, France; UMR CNRS-7276 INSERM-1262, Limoges University, Limoges, France.
Pierre-Francois LaterreDepartment of Critical Care Medicine, St Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium.
Richard S HotchkissDepartments of Anesthesiology, Medicine, and Surgery, Washington University School of Medicine, St Louis, MO 63110-1093, USA. Electronic address: richardshotchkiss@wustl.edu.
Lyle L MoldawerDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL 32610-0108, USA. Electronic address: lyle.moldawer@surgery.ufl.edu.
Inserm · FRWashington University in St. Louis · USCentre National de la Recherche Scientifique · FRFeinstein Institute for Medical Research · USFlorida College · USHôpital Edouard Herriot · FRUCLouvain · BEUniversity of Florida · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
Enhancing Innate and Adaptive Immunity to Improve Sepsis SurvivalR35GM126928 · NIGMS · WASHINGTON UNIVERSITY · PI Richard Samuel Hotchkiss · 2018 to 2026
$4.7M
Impact of Red Blood Cell (RBC)-Derived DAMPs on Host Immune Response in Pediatric SepsisK08GM129763 · NIGMS · WASHINGTON UNIVERSITY · PI REMY, KENNETH EUGENE · 2018 to 2021
$714k
NIA NIH HHS P30 AG028740NIGMS NIH HHS K08 GM129763NIGMS NIH HHS R35 GM126928
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BetacoronavirusCoronavirus InfectionsCOVID-19HumansImmunotherapyPandemicsPneumonia, ViralSARS-CoV-2Sepsis

Identifiers

PMID32444269
PMCPMC7195015
OpenAlexW3019247800

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.