Evidence map›Paper›PMID 32444146›Full record

ReviewJournal of sport and health science2020

Impacts of exercise intervention on various diseases in rats.

Ruwen Wang, Haili Tian, Dandan Guo, Qianqian Tian, Ting Yao, Xingxing Kong

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of sport and health science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 3 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 3 syntheses or guidelines pooled it, 102 citations in OpenAlex.

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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Ruwen WangSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
Haili TianSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
Dandan GuoSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
Qianqian TianSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
Ting YaoDivision of Pediatric Endocrinology, Department of Pediatrics, UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: tyao@mednet.ucla.edu.
Xingxing KongDivision of Pediatric Endocrinology, Department of Pediatrics, UCLA Children's Discovery and Innovation Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: xingxingkong@mednet.ucla.edu.
Shanghai University of Sport · CNMattel Children's Hospital · US

Funding

The Role of IRF4 in Exercise Induced ThermogenesisR00DK106550 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KONG, XINGXING · 2017 to 2019
$733k
NIDDK NIH HHS R00 DK106550
6 · The paper itself

Abstract

backgroundExercise is considered as an important intervention for treatment and prevention of several diseases, such as osteoarthritis, obesity, hypertension, and Alzheimer's disease. This review summarizes decadal exercise intervention studies with various rat models across 6 major systems to provide a better understanding of the mechanisms behind the effects that exercise brought.

methodsPubMed was utilized as the data source. To collect research articles, we used the following terms to create the search: (exercise [Title] OR physical activity [Title] OR training [Title]) AND (rats [Title/Abstract] OR rat [Title/Abstract] OR rattus [Title/Abstract]). To best cover targeted studies, publication dates were limited to "within 11 years." The exercise intervention methods used for different diseases were sorted according to the mode, frequency, and intensity of exercise.

resultsThe collected articles were categorized into studies related to 6 systems or disease types: motor system (17 articles), metabolic system (110 articles), cardiocerebral vascular system (171 articles), nervous system (71 articles), urinary system (2 articles), and cancer (21 articles). Our review found that, for different diseases, exercise intervention mostly had a positive effect. However, the most powerful effect was achieved by using a specific mode of exercise that addressed the characteristics of the disease.

conclusionAs a model animal, rats not only provide a convenient resource for studying human diseases but also provide the possibility for exploring the molecular mechanisms of exercise intervention on diseases. This review also aims to provide exercise intervention frameworks and optimal exercise dose recommendations for further human exercise intervention research.

Indexed as

Disease Models, AnimalExercise TherapyAnimalsCardiovascular DiseasesMetabolic DiseasesMusculoskeletal DiseasesNeoplasmsNervous System DiseasesPrimary PreventionRatsUrologic DiseasesCancerDiseaseExercise interventionMethodRatsSystem

Identifiers

PMID32444146
PMCPMC7242221
OpenAlexW2981903281

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.