ArticleBiochemical and biophysical research communications2020
Role of Arabidopsis INDOLE-3-ACETIC ACID CARBOXYL METHYLTRANSFERASE 1 in auxin metabolism.
Article in Biochemical and biophysical research communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 29 citations in OpenAlex.
- Conservation of IAMT Preference for Indole Acetic Acid Methylation Across 250 Million Years of Seed Plant Divergence, With Only One Recent Evolutionary Switch in Ocimum.Genome biology and evolution · 2026Article
- Mechanisms of auxin action in plant growth and development.Nature reviews. Molecular cell biology · 2025Review
- Phenylacetic acid metabolism in land plants: novel pathways and metabolites.Journal of experimental botany · 2025Article
- Spatiotemporal transcriptome and metabolome landscapes of cotton somatic embryos.Nature communications · 2025Article
- Comprehensive genomic and functional characterization of a phytoplasma associated with root retardation, early bolting, witches'-broom, and phyllody in daikon (Frontiers in microbiology · 2025Article
- Cytotoxic phenazine and antiallergic phenoxazine alkaloids from an arctic Nocardiopsis dassonvillei SCSIO 502F.Natural products and bioprospecting · 2023Article
- Chemical inhibition of the auxin inactivation pathway uncovers the roles of metabolic turnover in auxin homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Auxin methylation byProceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Arabidopsis ATP-Binding Cassette E protein ABCE2 is a conserved component of the translation machinery.Frontiers in plant science · 2022Article
- The main oxidative inactivation pathway of the plant hormone auxin.Nature communications · 2021Article
- A 24,482-bp deletion is associated with increased seed weight in Brassica napus L.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Auxin Metabolism in Plants.Cold Spring Harbor perspectives in biology · 2021Review
- UDP-glucosyltransferase UGT84B1 regulates the levels of indole-3-acetic acid and phenylacetic acid in Arabidopsis.Biochemical and biophysical research communications · 2020Article
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10 authors at 4 institutions in 2 countries.
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Abstract
The phytohormone auxin regulates a wide range of developmental processes in plants. Indole-3-acetic acid (IAA) is the main auxin that moves in a polar manner and forms concentration gradients, whereas phenylacetic acid (PAA), another natural auxin, does not exhibit polar movement. Although these auxins occur widely in plants, the differences between IAA and PAA metabolism remain largely unknown. In this study, we investigated the role of Arabidopsis IAA CARBOXYL METHYLTRANSFERASE 1 (IAMT1) in IAA and PAA metabolism. IAMT1 proteins expressed in Escherichia coli could convert both IAA and PAA to their respective methyl esters. Overexpression of IAMT1 caused severe auxin-deficient phenotypes and reduced the levels of IAA, but not PAA, in the root tips of Arabidopsis, suggesting that IAMT1 exclusively metabolizes IAA in vivo. We generated iamt1 null mutants via CRISPR/Cas9-mediated genome editing and found that the single knockout mutants had normal auxin levels and did not exhibit visibly altered phenotypes. These results suggest that other proteins, namely the IAMT1 homologs in the SABATH family of carboxyl methyltransferases, may also regulate IAA levels in Arabidopsis.
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