Evidence map›Paper›PMID 32443921›Full record

ArticleBiomolecules2020

Biological Properties of a Novel Multifunctional Host Defense Peptide from the Skin Secretion of the Chaco Tree Frog,

Carlos José Correia Santana, Ana Carolina Martins Magalhães, César Augusto Prías-Márquez, Diego A Falico, Agenor C M Dos Santos Júnior, Beatriz D Lima, Carlos André Ornelas Ricart, Denise Regina Bairros de Pilger, Rafaela Milan Bonotto, Carolina Borsoi Moraes and 7 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Update on antimicrobial peptides: key elements inThe Journal of general virology · 2025
    Review
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  8. Review
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Carlos José Correia SantanaLaboratory of Toxinology, Department of Physiological Sciences, Institute of Biology, University of Brasília, Brasília 70.910-900, Brazil.ORCID 0000-0001-9781-3670
Ana Carolina Martins MagalhãesLaboratory of Toxinology, Department of Physiological Sciences, Institute of Biology, University of Brasília, Brasília 70.910-900, Brazil.
César Augusto Prías-MárquezLaboratory of Toxinology, Department of Physiological Sciences, Institute of Biology, University of Brasília, Brasília 70.910-900, Brazil.
Diego A FalicoLaboratory of Toxinology, Department of Physiological Sciences, Institute of Biology, University of Brasília, Brasília 70.910-900, Brazil.
Agenor C M Dos Santos JúniorLaboratory of Protein Chemistry and Biochemistry, Department of Cell Biology, Institute of Biology, University of Brasília, Brasília 70.910-900, Brazil.
Beatriz D LimaLaboratory of Gene Biology, Department of Cell Biology, University of Brasília, Brasília 70.910-900, Brazil.
Carlos André Ornelas RicartLaboratory of Protein Chemistry and Biochemistry, Department of Cell Biology, Institute of Biology, University of Brasília, Brasília 70.910-900, Brazil.
Denise Regina Bairros de PilgerDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05.508-900, Brazil.
Rafaela Milan BonottoDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05.508-900, Brazil.
Carolina Borsoi MoraesDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05.508-900, Brazil.ORCID 0000-0002-0689-2770
Lúcio H Freitas-JúniorDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05.508-900, Brazil.
Alice da Cunha Morales ÁlvaresLaboratory of Biophysics, Department of Cell Biology, Institute of Biology, University of Brasília, Brasília 70.910-900, Brazil.
Sonia Maria FreitasLaboratory of Biophysics, Department of Cell Biology, Institute of Biology, University of Brasília, Brasília 70.910-900, Brazil.
Isabelle S LuzLaboratory of Protein Chemistry and Biochemistry, Department of Cell Biology, Institute of Biology, University of Brasília, Brasília 70.910-900, Brazil.ORCID 0000-0001-8722-5103
Osmindo Rodrigues PiresLaboratory of Toxinology, Department of Physiological Sciences, Institute of Biology, University of Brasília, Brasília 70.910-900, Brazil.
Wagner FontesLaboratory of Protein Chemistry and Biochemistry, Department of Cell Biology, Institute of Biology, University of Brasília, Brasília 70.910-900, Brazil.ORCID 0000-0001-5140-8573
Mariana S CastroLaboratory of Toxinology, Department of Physiological Sciences, Institute of Biology, University of Brasília, Brasília 70.910-900, Brazil.
Universidade de Brasília · BRUniversidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, the number of new antimicrobial drugs launched on the market has decreased considerably even though there has been an increase in the number of resistant microbial strains. Thus, antimicrobial resistance has become a serious public health problem. Amphibian skin secretions are a rich source of host defense peptides, which generally are cationic and hydrophobic molecules, with a broad-spectrum of activity. In this study, one novel multifunctional defense peptide was isolated from the skin secretion of the Chaco tree frog,

Indexed as

Amphibian ProteinsAnimalsAnuraArbovirusesBacteriaCandidaCell Line, TumorCell ProliferationCells, CulturedDefensinsHemolysisHumansNeutrophilsProtein Conformation, alpha-HelicalSkinTrypanosoma cruziAmphibian ProteinsDefensinsamphibianantimicrobial peptideBoana ranicepsmultifunctional defense peptideneutrophilsskin secretionstructural analysis

Identifiers

PMID32443921
PMCPMC7277517
OpenAlexW3027972870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.