Evidence map›Paper›PMID 3244386›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology1988

Multiple effects of caffeine on contraction and cytosolic free Ca2+ levels in vascular smooth muscle of rat aorta.

K Sato, H Ozaki, H Karaki

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 90 citations in OpenAlex.

  1. Article
  2. Inhibition of PKC-dependent extracellular Ca2+ entry contributes to the depression of contractile activity in long-term pressure-overloaded endothelium-denuded rat aortas.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2014
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

K SatoDepartment of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo, Japan.
H Ozaki
H Karaki
The University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1. Effects of caffeine on cytosolic Ca2+ level ([Ca2+]cyt), measured simultaneously with muscle tension using fura-2-Ca2+ fluorescence, were examined in isolated smooth muscle of rat aorta. 2. Caffeine (20 mmol/l) induced a large transient increase in [Ca2+]cyt followed by a plateau which was higher than resting level. However, muscle tension showed a transient increase followed by a decrease to or below the resting level. In Ca2+-free solution, caffeine induced only a transient increase in both [Ca2+]cyt and muscle tension. 3. At low temperature (22 degrees C), high K+ (72.7 mmol/l) induced sustained increase in both [Ca2+]cyt and muscle tension which were smaller than those observed at 37 degrees C. At 22 degrees C, however, caffeine-induced transient changes were greater than those observed at 37 degrees C. 4. Ryanodine (10 mumol/l) inhibited the transient changes due to caffeine but showed little effects on the sustained changes due to high K+. 5. During the sustained increase in [Ca2+]cyt induced by noradrenaline (10 mumol/l) or high K+ (140 mmol/l), addition of caffeine transiently increased [Ca2+]cyt followed by a decrease to a level slightly lower than that before the addition of caffeine. In contrast to this, muscle tension transiently increased and then decreased to or below the resting level. 6. These results suggest that caffeine-induced contraction is due to the release of Ca2+ from cellular store. Caffeine also has an inhibitory effect which is partly attributable to decrease in [Ca2+]cyt and partly to the decrease in the sensitivity to Ca2+ of the contractile elements.

Indexed as

AnimalsAorta, ThoracicCaffeineCalciumCytosolIn Vitro TechniquesMaleMuscle ContractionMuscle, Smooth, VascularPotassiumRatsRats, Inbred StrainsRyanodineTemperatureCaffeineCalciumPotassiumRyanodine

Identifiers

PMID3244386
OpenAlexW2040980719

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.