Evidence map›Paper›PMID 32443852›Full record

ArticleGenes2020

MicroRNA-1253 Regulation of WASF2 (WAVE2) and its Relevance to Racial Health Disparities.

Mercy A Arkorful, Nicole Noren Hooten, Yongqing Zhang, Amirah N Hewitt, Lori Barrientos Sanchez, Michele K Evans, Douglas F Dluzen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. MicroRNAs and Cancer Racial Disparities.Wiley interdisciplinary reviews. RNA
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mercy A ArkorfulDepartment of Biology, Morgan State University, Baltimore, MD 21251, USA.
Nicole Noren HootenLaboratory of Epidemiology and Population Science, National Institute on Aging, Baltimore, MD 21224, USA.ORCID 0000-0002-1683-3838
Yongqing ZhangLaboratory of Genetics and Genomics, National Institute on Aging, Baltimore, MD 21224, USA.
Amirah N HewittLaboratory of Epidemiology and Population Science, National Institute on Aging, Baltimore, MD 21224, USA.
Lori Barrientos SanchezLaboratory of Epidemiology and Population Science, National Institute on Aging, Baltimore, MD 21224, USA.
Michele K EvansLaboratory of Epidemiology and Population Science, National Institute on Aging, Baltimore, MD 21224, USA.
Douglas F DluzenDepartment of Biology, Morgan State University, Baltimore, MD 21251, USA.
National Institute on Aging · USMorgan State University · US

Funding

Wastewater surveillance for addressing environmental health disparitiesU54MD013376 · NIMHD · MORGAN STATE UNIVERSITY · PI Paul B. Tchounwou · 2019 to 2026
$33.5M
ASCEND Training Model to Increase Diversity in the Biomedical Research WorkforceTL4GM118974 · NIGMS · MORGAN STATE UNIVERSITY · PI HOHMANN, CHRISTINE F, SHEIKHATTARI, PAYAM · 2015 to 2023
$9.5M
RISE REACHeSR25GM058904 · NIGMS · MORGAN STATE UNIVERSITY · PI WINSTEAD, ANGELA J · 1999 to 2023
$6.7M
Division of Intramural Research, National Institute on Aging AG000519NIGMS NIH HHS R25 GM058904NIGMS NIH HHS TL4GM118974NIMHD NIH HHS U54 MD013376
6 · The paper itself

Abstract

The prevalence of hypertension among African Americans (AAs) in the US is among the highest of any demographic and affects over two-thirds of AA women. Previous data from our laboratory suggest substantial differential gene expression (DGE) of mRNAs and microRNAs (miRNAs) exists within peripheral blood mononuclear cells (PBMCs) isolated from AA and white women with or without hypertension. We hypothesized that DGE by race may contribute to racial differences in hypertension. In a reanalysis of our previous dataset, we found that the Wiskott-Aldrich syndrome protein Verprolin-homologous protein 2 (WASF2 (also known as WAVE2)) is differentially expressed in AA women with hypertension, along with several other members of the actin cytoskeleton signaling pathway that plays a role in cell shape and branching of actin filaments. We performed an in silico miRNA target prediction analysis that suggested miRNA miR-1253 regulates WASF2. Transfection of miR-1253 mimics into human umbilical vein endothelial cells (HUVECs) and human aortic endothelial cells (HAECs) significantly repressed WASF2 mRNA and protein levels (

Indexed as

RacismActin CytoskeletonBlack or African AmericanFemaleGene Expression RegulationHumansHuman Umbilical Vein Endothelial CellsHypertensionLeukocytes, MononuclearMaleMicroRNAsRNA, MessengerWhite PeopleWiskott-Aldrich SyndromeWiskott-Aldrich Syndrome Protein FamilyMicroRNAsRNA, MessengerWASF2 protein, humanWiskott-Aldrich Syndrome Protein Familyactin cytoskeletal regulatorsAfrican Americandifferential gene expressionendothelial cellhealth disparitieshypertensionmicroRNAracewomen

Identifiers

PMID32443852
PMCPMC7288301
OpenAlexW3028434387

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.