Evidence map›Paper›PMID 32443726›Full record

ArticleInternational journal of molecular sciences2020

Zygotic Vsx1 Plays a Key Role in Defining V2a Interneuron Sub-Lineage by Directly Repressing

Qi Zhang, Haomang Xu, Wei Zhao, Jianbo Zheng, Lei Sun, Chen Luo

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In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Qi ZhangCollege of Life Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-9207-858X
Haomang XuCollege of Life Sciences, Zhejiang University, Hangzhou 310058, China.
Wei ZhaoCollege of Life Sciences, Zhejiang University, Hangzhou 310058, China.
Jianbo ZhengCollege of Life Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0001-6795-0252
Lei SunCollege of Life Sciences, Zhejiang University, Hangzhou 310058, China.
Chen LuoCollege of Life Sciences, Zhejiang University, Hangzhou 310058, China.
Zhejiang University · CNZhejiang Institute of Freshwater Fisheries · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the spinal cord, excitatory V2a and inhibitory V2b interneurons are produced together by the final division of common P2 progenitors. During V2a and V2b diversification, Tal1 is necessary and sufficient to promote V2b differentiation and Vsx2 suppresses the expression of motor neuron genes to consolidate V2a interneuron identity. The expression program of Tal1 is triggered by a Foxn4-driven regulatory network in the common P2 progenitors. Why the expression of Tal1 is inhibited in V2a interneurons at the onset of V2a and V2b sub-lineage diversification remains unclear. Since transcription repressor Vsx1 is expressed in the P2 progenitors and newborn V2a cells in zebrafish, we investigated the role of Vsx1 in V2a fate specification during V2a and V2b interneuron diversification in this species by loss and gain-of-function experiments. In

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsCell LineageEye ProteinsHomeodomain ProteinsInterneuronsNeurogenesisPromoter Regions, GeneticProtein BindingSpinal CordT-Cell Acute Lymphocytic Leukemia Protein 1ZebrafishZebrafish ProteinsEye ProteinsHomeodomain Proteinstal1 protein, zebrafishT-Cell Acute Lymphocytic Leukemia Protein 1vsx1 protein, zebrafishZebrafish Proteinsspinal cordTal1transcriptional repressionV2a interneuron specificationV2 interneuron diversificationVsx1zebrafish

Identifiers

PMID32443726
PMCPMC7279403
OpenAlexW3028230363

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.