Evidence map›Paper›PMID 32443685›Full record

ReviewJournal of clinical medicine2020

Present and Future of Bronchopulmonary Dysplasia.

Luca Bonadies, Patrizia Zaramella, Andrea Porzionato, Giorgio Perilongo, Maurizio Muraca, Eugenio Baraldi

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 4 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 4 syntheses or guidelines pooled it, 127 citations in OpenAlex.

  1. Pooled it
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  5. Trial
  6. Article
  7. Review
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  11. Bronchopulmonary dysplasia and extremely preterm birth: time for a broader perspective on long-term outcomes.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  12. Observational
  13. Review
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  15. Article
  16. Article
  17. [Role ofZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
    Article
  18. Article
  19. Review
  20. Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Luca BonadiesNeonatal Intensive Care Unit, Department of Women's and Children's Health, University of Padova, 35128 Padova, Italy.ORCID 0000-0001-7700-3056
Patrizia ZaramellaNeonatal Intensive Care Unit, Department of Women's and Children's Health, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-7471-8379
Andrea PorzionatoHuman Anatomy Section, Department of Neurosciences, University of Padova, 35128 Padova, Italy.
Giorgio PerilongoDepartment of Women's and Children's Health, University of Padova, 35128 Padova, Italy.
Maurizio MuracaInstitute of Pediatric Research "Città della Speranza", Stem Cell and Regenerative Medicine Laboratory, Department of Women's and Children's Health, University of Padova, 35128 Padova, Italy.
Eugenio BaraldiNeonatal Intensive Care Unit, Department of Women's and Children's Health, University of Padova, 35128 Padova, Italy.
University of Padua · ITCittà della Speranza Foundation · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bronchopulmonary dysplasia (BPD) is the most common respiratory disorder among infants born extremely preterm. The pathogenesis of BPD involves multiple prenatal and postnatal mechanisms affecting the development of a very immature lung. Their combined effects alter the lung's morphogenesis, disrupt capillary gas exchange in the alveoli, and lead to the pathological and clinical features of BPD. The disorder is ultimately the result of an aberrant repair response to antenatal and postnatal injuries to the developing lungs. Neonatology has made huge advances in dealing with conditions related to prematurity, but efforts to prevent and treat BPD have so far been only partially effective. Seeing that BPD appears to have a role in the early origin of chronic obstructive pulmonary disease, its prevention is pivotal also in long-term respiratory outcome of these patients. There is currently some evidence to support the use of antenatal glucocorticoids, surfactant therapy, protective noninvasive ventilation, targeted saturations, early caffeine treatment, vitamin A, and fluid restriction, but none of the existing strategies have had any significant impact in reducing the burden of BPD. New areas of research are raising novel therapeutic prospects, however. For instance, early topical (intratracheal or nebulized) steroids seem promising: they might help to limit BPD development without the side effects of systemic steroids. Evidence in favor of stem cell therapy has emerged from several preclinical trials, and from a couple of studies in humans. Mesenchymal stromal/stem cells (MSCs) have revealed a reparatory capability, preventing the progression of BPD in animal models. Administering MSC-conditioned media containing extracellular vesicles (EVs) have also demonstrated a preventive action, without the potential risks associated with unwanted engraftment or the adverse effects of administering cells. In this paper, we explore these emerging treatments and take a look at the revolutionary changes in BPD and neonatology on the horizon.

Indexed as

bronchopulmonary dysplasiaextracellular vesiclesmesenchymal stem cellsmesenchymal stromal cellsneonatal ICU

Identifiers

PMID32443685
PMCPMC7290764
OpenAlexW3026767100

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.