Evidence map›Paper›PMID 32443673›Full record

ArticleInternational journal of molecular sciences2020

Placental Microarray Profiling Reveals Common mRNA and lncRNA Expression Patterns in Preeclampsia and Intrauterine Growth Restriction.

Diana Medina-Bastidas, Mario Guzmán-Huerta, Hector Borboa-Olivares, César Ruiz-Cruz, Sandra Parra-Hernández, Arturo Flores-Pliego, Ivan Salido-Guadarrama, Lisbeth Camargo-Marín, Eliakym Arambula-Meraz, Guadalupe Estrada-Gutierrez

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Diana Medina-BastidasUnidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México, Mexico City 11000, Mexico.
Mario Guzmán-HuertaDepartamento de Medicina Traslacional, Instituto Nacional de Perinatología, Mexico City 11000, Mexico.
Hector Borboa-OlivaresSubdirección de Investigación en Intervenciones Comunitarias, Instituto Nacional de Perinatología, Mexico City 11000, Mexico.
César Ruiz-CruzHospital de Ginecología y Obstetricia No. 4, Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, Mexico City 01090, Mexico.
Sandra Parra-HernándezLaboratorio de Inmunobioquímica, Instituto Nacional de Perinatología, Mexico City 11000, Mexico.
Arturo Flores-PliegoLaboratorio de Inmunobioquímica, Instituto Nacional de Perinatología, Mexico City 11000, Mexico.ORCID 0000-0001-7876-6098
Ivan Salido-GuadarramaLaboratorio de Biología Computacional, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.
Lisbeth Camargo-MarínDepartamento de Medicina Traslacional, Instituto Nacional de Perinatología, Mexico City 11000, Mexico.
Eliakym Arambula-MerazLaboratorio de Genética y Biología Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Culiacan 80040, Mexico.ORCID 0000-0003-1026-7430
Guadalupe Estrada-GutierrezDirección de Investigación, Instituto Nacional de Perinatología, Mexico City 11000, Mexic.ORCID 0000-0001-9551-9021
Instituto Nacional de Perinatología · MXInstituto Nacional de Enfermedades Respiratorias · MXMexican Social Security Institute · MXUniversidad Autónoma de Sinaloa · MX

Funding

Instituto Nacional de Perinatología 2230-10101-01-16
6 · The paper itself

Abstract

Preeclampsia (PE) and Intrauterine Growth Restriction (IUGR) are major contributors to perinatal morbidity and mortality. These pregnancy disorders are associated with placental dysfunction and share similar pathophysiological features. The aim of this study was to compare the placental gene expression profiles including mRNA and lncRNAs from pregnant women from four study groups: PE, IUGR, PE-IUGR, and normal pregnancy (NP). Gene expression microarray analysis was performed on placental tissue obtained at delivery and results were validated using RTq-PCR. Differential gene expression analysis revealed that the largest transcript variation was observed in the IUGR samples compared to NP (

Indexed as

TranscriptomeAdultBirth WeightFemaleFetal Growth RetardationHumansInfant, NewbornMalePlacentaPre-EclampsiaPregnancyRNA, Long NoncodingRNA, MessengerRNA, Long NoncodingRNA, Messengergene expressionintrauterine growth restrictionLncRNAmicroarrayplacentapreeclampsia

Identifiers

PMID32443673
PMCPMC7279523
OpenAlexW3028578004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.