ArticleMolecular and cellular biology1988
Isolation and characterization of a cDNA that encodes mouse fibroblast tropomyosin isoform 2.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 27 citations in OpenAlex.
- Comprehensive profiling of circular RNAs with nanopore sequencing and CIRI-long.Nature biotechnology · 2021Article
- Tropomyosin-2 cDNA lacking the 3' untranslated region riboregulator induces growth inhibition of v-Ki-ras-transformed fibroblasts.Molecular biology of the cell · 1997Article
- Clinical implications of hypertrophic cardiomyopathy associated with mutations in the alpha-tropomyosin gene.Heart (British Cardiac Society) · 1996Article
- Chromosome mapping of nine tropomyosin-related sequences in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- Binding of pEL98 protein, an S100-related calcium-binding protein, to nonmuscle tropomyosin.The Journal of cell biology · 1994Article
- Avian cardiac tropomyosin gene produces tissue-specific isoforms through alternative RNA splicing.Journal of muscle research and cell motility · 1992Article
- Three novel brain tropomyosin isoforms are expressed from the rat alpha-tropomyosin gene through the use of alternative promoters and alternative RNA processing.Molecular and cellular biology · 1990Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
We isolated and characterized a cDNA clone encoding tropomyosin isoform 2 (TM2) from a mouse fibroblast cDNA library. TM2 was found to contain 284 amino acids and was closely related to the rat smooth and skeletal muscle alpha-TMs and the human fibroblast TM3. The amino acid sequence of TM2 showed a nearly complete match with that of human fibroblast TM3 except for the region from amino acids 189 to 213, the sequence of which was identical to those of rat smooth and skeletal muscle alpha-TMs. These results suggest that TM2 is expressed from the same gene that encodes the smooth muscle alpha-TM, the skeletal muscle alpha-TM, and TM3 via an alternative RNA-splicing mechanism. Comparison of the expression of TM2 mRNA in low-metastatic Lewis lung carcinoma P29 cells and high-metastatic D6 cells revealed that it was significantly less in D6 cells than in P29 cells, supporting our previous observations (K. Takenaga, Y. Nakamura, and S. Sakiyama, Mol. Cell. Biol. 8:3934-3937, 1988) at the protein level.
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