Evidence map›Paper›PMID 32443632›Full record

ReviewInternational journal of molecular sciences2020

Expression of Genes Involved in Axon Guidance: How Much Have We Learned?

Sung Wook Kim, Kyong-Tai Kim

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. The effects of NMolecular and cellular biochemistry · 2023
    Review
  7. Article
  8. Aging · 2022
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Gene Expression in the Physiology and Pathology of Neurons.International journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sung Wook KimDepartment of Life Sciences, Pohang University of Science and Technology, Pohang 37673, Korea.ORCID 0000-0001-9572-4762
Kyong-Tai KimDepartment of Life Sciences, Pohang University of Science and Technology, Pohang 37673, Korea.
Pohang University of Science and Technology · KR

Funding

Ministry of Education, Science and Technology 10Z20130012243National Research Foundation of Korea 2017M3C7A1023478National Research Foundation of Korea 2019R1A2C2009440National Research Foundation of Korea PJ01324801
6 · The paper itself

Abstract

Neuronal axons are guided to their target during the development of the brain. Axon guidance allows the formation of intricate neural circuits that control the function of the brain, and thus the behavior. As the axons travel in the brain to find their target, they encounter various axon guidance cues, which interact with the receptors on the tip of the growth cone to permit growth along different signaling pathways. Although many scientists have performed numerous studies on axon guidance signaling pathways, we still have an incomplete understanding of the axon guidance system. Lately, studies on axon guidance have shifted from studying the signal transduction pathways to studying other molecular features of axon guidance, such as the gene expression. These new studies present evidence for different molecular features that broaden our understanding of axon guidance. Hence, in this review we will introduce recent studies that illustrate different molecular features of axon guidance. In particular, we will review literature that demonstrates how axon guidance cues and receptors regulate local translation of axonal genes and how the expression of guidance cues and receptors are regulated both transcriptionally and post-transcriptionally. Moreover, we will highlight the pathological relevance of axon guidance molecules to specific diseases.

Indexed as

Axon GuidanceProtein BiosynthesisAnimalsAxonsGene Expression RegulationHumansRNA-Binding ProteinsSignal TransductionRNA-Binding Proteinsaxon guidancelocal translationRNA binding proteins

Identifiers

PMID32443632
PMCPMC7278939
OpenAlexW3024657574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.