ArticleMarine drugs2020
Effect of Chitosan as a Cross-Linker on Matrix Metalloproteinase Activity and Bond Stability with Different Adhesive Systems.
Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Pooled it
- Effect of collagen cross-linkers on dentin bond strength: A systematic review and network meta-analysis.Frontiers in bioengineering and biotechnology · 2022Pooled it
- Er:YAG laser in selective caries removal and dentin treatment with chitosan: a randomized clinical trial in primary molars.Lasers in medical science · 2023Trial
- Effect of Bond Strength of Chitosan Containing Cavity Disinfectant on Deep or Superficial Dentin.Biomimetics (Basel, Switzerland) · 2026Article
- Effect of incorporating chitosan/hydroxyapatite composite nanoparticles into a universal adhesive on bonding efficacy to caries-affected dentin and bioactivity.BMC oral health · 2026Article
- Effect of chitosan and chlorhexidine on demineraslised dentin to enhance adhesion.Bioinformation · 2025Article
- Effects of proanthocyanidin-functionalized hydroxyapatite nanoparticles on dentin bonding.Clinical oral investigations · 2024Article
- Effect of Salvadora persica on resin-dentin bond stability.BMC oral health · 2024Article
- Effect of chitosan and CMCS on dentin after Er:YAG laser irradiation: shear bond strength and surface morphology analysis.BMC oral health · 2024Article
- Pomegranate extract on eroded dentin: antioxidant action, bond strength and morphology of the adhesive interface after aging.Restorative dentistry & endodontics · 2024Article
- Impact of Dentine Pretreatment with Matrix Metalloproteinase Inhibitors on Bond Strength of Coronal Composite Restorations: A Systematic Review and Meta-analysis of In Vitro Studies.European journal of dentistry · 2023Article
- Evaluating the Effect of Sumac Extract on Dentine Micro-Hardness during pH Cycling.Journal of dentistry (Shiraz, Iran) · 2023Article
- Can Carbodiimide (EDC) and Chitosan Cross-linking Agents Effect the Longevity of Fiberglass Posts Luted with Different Types of Composite Cements to Root Dentin?The journal of adhesive dentistry · 2023Article
- Chitosan-induced biomodification on demineralized dentin to improve the adhesive interface.Restorative dentistry & endodontics · 2022Article
- The Influence of Different Bleaching Protocols on Dentinal Enzymatic Activity: An In Vitro Study.Molecules (Basel, Switzerland) · 2022Article
- Endogenous Enzymatic Activity in Dentin Treated with a Chitosan Primer.International journal of molecular sciences · 2021Article
- Bond Strength of Universal Adhesives to Dentin: A Systematic Review and Meta-Analysis.Polymers · 2021Review
- Chitosan improves the durability of resin-dentin interface with etch-and-rinse or self-etch adhesive systems.Journal of applied oral science : revista FOB · 2021Article
- Bibliometric Analysis of Literature Published on Antibacterial Dental Adhesive from 1996-2020.Polymers · 2020Review
- Microtensile resistance of an adhesive system modified with chitosan nanoparticles.Journal of conservative dentistry : JCDArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 5 countries.
Funding
Abstract
The aim of the present study was to evaluate the effect of 0.1% chitosan (Ch) solution as an additional primer on the mechanical durability and enzymatic activity on dentine using an etch-and-rinse (E&R) adhesive and a universal self-etch (SE) adhesive. Microtensile bond strength and interfacial nanoleakage expression of the bonded interfaces for all adhesives (with or without pretreatment with 0.1% Ch solution for 1 min and air-dried for 5 seconds) were analyzed immediately and after 10,000 thermocycles. Zymograms of protein extracts from human dentine powder incubated with Optibond FL and Scotchbond Universal on untreated or Ch-treated dentine were obtained to examine dentine matrix metalloproteinase (MMP) activities. The use of 0.1% Ch solution as an additional primer in conjunction with the E&R or SE adhesive did not appear to have influenced the immediate bond strength (T0) or bond strength after thermocycling (T1). Zymography showed a reduction in MMP activities only for mineralized and demineralized dentine powder after the application of Ch. Application of 0.1% Ch solution does not increase the longevity of resin-dentine bonds. Nonetheless, the procedure appears to be proficient in reducing dentine MMP activities within groups without adhesive treatments. Further studies are required to comprehend the cross-linking of Ch with dentine collagen.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.