ArticleMolecular and cellular biology1988
Regulatory myosin light-chain genes of Caenorhabditis elegans.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- Molecular cloning, sequence identification and expression analysis of novel caprine MYLPF gene.Molecular biology reports · 2013Article
- A proteomic view of Caenorhabditis elegans caused by short-term hypoxic stress.Proteome science · 2010Article
- Molecular characterization of numr-1 and numr-2: genes that increase both resistance to metal-induced stress and lifespan in Caenorhabditis elegans.Journal of cell science · 2010Article
- An integrated strategy to study muscle development and myofilament structure in Caenorhabditis elegans.PLoS genetics · 2009Article
- Molecular characterization of two homologs of the Caenorhabditis elegans cadmium-responsive gene cdr-1: cdr-4 and cdr-6.Journal of molecular biology · 2008Article
- Role of phosphatidylinositol-4-phosphate 5' kinase (ppk-1) in ovulation of Caenorhabditis elegans.Experimental cell research · 2007Article
- Functions of the Caenorhabditis elegans regulatory myosin light chain genes mlc-1 and mlc-2.Genetics · 1998Article
- Splicing removes the Caenorhabditis elegans transposon Tc1 from most mutant pre-mRNAs.Molecular and cellular biology · 1996Article
- The Caenorhabditis elegans muscle-affecting gene unc-87 encodes a novel thin filament-associated protein.The Journal of cell biology · 1994Article
- Imprecise excision of the Caenorhabditis elegans transposon Tc1 creates functional 5' splice sites.Molecular and cellular biology · 1994Article
- Genes critical for muscle development and function in Caenorhabditis elegans identified through lethal mutations.The Journal of cell biology · 1994Article
- Sequence requirements for myosin gene expression and regulation in Caenorhabditis elegans.Genetics · 1993Article
- Site-selected insertion of the transposon Tc1 into a Caenorhabditis elegans myosin light chain gene.Molecular and cellular biology · 1993Article
- Insertion of part of an intron into the 5' untranslated region of a Caenorhabditis elegans gene converts it into a trans-spliced gene.Molecular and cellular biology · 1991Article
- Information content of Caenorhabditis elegans splice site sequences varies with intron length.Nucleic acids research · 1990Article
- The role of sdc-1 in the sex determination and dosage compensation decisions in Caenorhabditis elegans.Genetics · 1990Article
- The Caenorhabditis elegans gene sdc-2 controls sex determination and dosage compensation in XX animals.Genetics · 1989Article
- Genetic analysis of myosin assembly in Caenorhabditis elegans.Molecular neurobiologyReview
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2 authors at 1 institution in 1 country.
Funding
Abstract
We have cloned and analyzed the Caenorhabditis elegans regulatory myosin light-chain genes. C. elegans contains two such genes, which we have designated mlc-1 and mlc-2. The two genes are separated by 2.6 kilobases and are divergently transcribed. We determined the complete nucleotide sequences of both mlc-1 and mlc-2. A single, conservative amino acid substitution distinguishes the sequences of the two proteins. The C. elegans proteins are strongly homologous to regulatory myosin light chains of Drosophila melanogaster and vertebrates and weakly homologous to a superfamily of eucaryotic calcium-binding proteins. Both mlc-1 and mlc-2 encode abundant mRNAs. We mapped the 5' termini of these transcripts by using primer extension sequencing of mRNA templates. mlc-1 mRNAs initiate within conserved hexanucleotides at two different positions, located at -28 and -38 relative to the start of translation. The 5' terminus of mlc-2 mRNA is not encoded in the 4.8-kilobase genomic region upstream of mlc-2. Rather, mlc-2 mRNA contains at its 5' end a short, untranslated leader sequence that is identical to the trans-spliced leader sequence of three C. elegans actin genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.