Evidence map›Paper›PMID 32443539›Full record

ArticleInternational journal of molecular sciences2020

Genetic Susceptibility to Chronic Liver Disease in Individuals from Pakistan.

Asad Mehmood Raja, Ester Ciociola, Imran Nazir Ahmad, Faisal Saud Dar, Syed Muhammad Saqlan Naqvi, Muhammad Moaeen-Ud-Din, Ghazala Kaukab Raja, Stefano Romeo, Rosellina Margherita Mancina

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Observational
  2. Hepatogenomics of MAFLD in Asian Population: Genetic Polymorphisms and Pathway-Based Insights.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
    Review
  3. Review
  4. Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  5. Article
  6. Article
  7. Prevalence ofJournal of obesity · 2023
    Article
  8. Effect of common genetic variants on the risk of cirrhosis in non-alcoholic fatty liver disease during 20 years of follow-up.Liver international : official journal of the International Association for the Study of the Liver · 2022
    Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Asad Mehmood RajaUniversity Institute of Biochemistry and Biotechnology, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi 46300, Pakistan.
Ester CiociolaDepartment of Molecular and Clinical Medicine, The Sahlgrenska Academy at the University of Gothenburg, Wallenberg Laboratory, 413 45 Gothenburg, Sweden.
Imran Nazir AhmadDepartment of Pathology and Laboratory Medicine, Shifa International Hospitals Ltd., Islamabad 44790, Pakistan.
Faisal Saud DarLiver Transplantation, Hepatobiliary and Pancreatic Services Unit, Shifa International Hospitals Ltd., Islamabad 44790, Pakistan.
Syed Muhammad Saqlan NaqviUniversity Institute of Biochemistry and Biotechnology, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi 46300, Pakistan.
Muhammad Moaeen-Ud-DinDepartment of Animal Breeding and Genetics/National Center for Livestock Breeding, Genetics & Genomics, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi 46300, Pakistan.
Ghazala Kaukab RajaUniversity Institute of Biochemistry and Biotechnology, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi 46300, Pakistan.
Stefano RomeoDepartment of Molecular and Clinical Medicine, The Sahlgrenska Academy at the University of Gothenburg, Wallenberg Laboratory, 413 45 Gothenburg, Sweden.
Rosellina Margherita MancinaDepartment of Molecular and Clinical Medicine, The Sahlgrenska Academy at the University of Gothenburg, Wallenberg Laboratory, 413 45 Gothenburg, Sweden.ORCID 0000-0002-1126-3071
Pir Mehr Ali Shah Arid Agriculture University · PKShifa International Hospital · PKUniversity of Gothenburg · SESahlgrenska University Hospital · SE

Funding

AstraZeneca Agreement for ResearchDiabetesfonden DIA 2017-205International Research Support Initiative Program (1-8/HEC/HRD/2018/8121) awarded by Higher Education Commission of Pakistan PIN: IRSIP 42 BMS 25Knut och Alice Wallenbergs Stiftelse KAW 2017.0203Novo Nordisk Foundation Center for Basic Metabolic Research Excellence Project, 9321-430Novo Nordisk Foundation Center for Basic Metabolic Research Project grants in Endocrinology and MetabolismStiftelsen för Strategisk Forskning SSF ITM17-0384Swedish state under the Agreement between the Swedish government and the county councils the ALF agreement, SU 2018-04276the Swedish Heart Lung Foundation 20120533Vetenskapsrådet 2016-01527
6 · The paper itself

Abstract

Chronic liver disease, with viral or non-viral etiology, is endemic in many countries and is a growing burden in Asia. Among the Asian countries, Pakistan has the highest prevalence of chronic liver disease. Despite this, the genetic susceptibility to chronic liver disease in this country has not been investigated. We performed a comprehensive analysis of the most robustly associated common genetic variants influencing chronic liver disease in a cohort of individuals from Pakistan. A total of 587 subjects with chronic liver disease and 68 healthy control individuals were genotyped for the

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single Nucleotide17-Hydroxysteroid DehydrogenasesAcyltransferasesAdaptor Proteins, Signal TransducingAdultChronic DiseaseFemaleGenetic Association StudiesHumansLipaseLiver DiseasesMaleMembrane ProteinsMiddle AgedNon-alcoholic Fatty Liver Disease17-Hydroxysteroid DehydrogenasesAcyltransferasesAdaptor Proteins, Signal TransducingGCKR protein, humanHSD17B13 protein, humanLipaseMBOAT7 protein, humanMembrane ProteinsPhospholipases A2, Calcium-IndependentPNPLA3 protein, humanadiponutrinADPNAsiaLPIAT1NAFLDTMC4

Identifiers

PMID32443539
PMCPMC7278956
OpenAlexW3025729369

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.