Evidence map›Paper›PMID 32443529›Full record

ArticleViruses2020

External Quality Assessment Program for Next-Generation Sequencing-Based HIV Drug Resistance Testing: Logistical Considerations.

Hezhao Ji, Neil Parkin, Feng Gao, Thomas Denny, Cheryl Jennings, Paul Sandstrom, Rami Kantor

Abstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hezhao JiNational HIV and Retrovirology Laboratories at JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
Neil ParkinData First Consulting Inc., Sebastopol, CA 95472, USA.
Feng GaoDuke Human Vaccine Institute and Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0001-8903-0203
Thomas DennyDuke Human Vaccine Institute and Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Cheryl JenningsDepartment of Molecular Pathogens and Immunity, Rush University, Chicago, IL 60612, USA.
Paul SandstromNational HIV and Retrovirology Laboratories at JC Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada.
Rami KantorDivision of Infectious Diseases, Brown University Alpert Medical School, Providence, RI 02906, USA.ORCID 0000-0003-3659-1108

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI CURT G BECKWITH · 1998 to 2026
$51.7M
NIAID VIROLOGY QUALITY ASSURANCE (VQA) COVID-1975N93019C00015 · NIAID · DUKE UNIVERSITY · PI DENNY, THOMAS · 2019 to 2025
$24.4M
Addressing HIV drug resistance research gaps in a cohort of perinatally infected Kenyan children and adolescentsR01AI147333 · NIAID · MIRIAM HOSPITAL · PI KANTOR, RAMI, VREEMAN, RACHEL CHRISTINE · 2019 to 2024
$3.9M
Real Time Phylogeny and Contact Tracing to Disrupt HIV TransmissionR01AI136058 · NIAID · MIRIAM HOSPITAL · PI KANTOR, RAMI · 2018 to 2022
$3.4M
HIV Treatment Failure and Drug Resistance in Western Kenyan ChildrenR01AI120792 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI KANTOR, RAMI, VREEMAN, RACHEL CHRISTINE · 2016 to 2019
$2.9M
Real Time Phylogeny and Contact Tracing to Disrupt HIV TransmissionR37AI136058 · NIAID · MIRIAM HOSPITAL · PI Rami Kantor · 2025 to 2026
$1.5M
HIV Drug Resistance, Monitoring and TransmissionK24AI134359 · NIAID · MIRIAM HOSPITAL · PI Rami Kantor · 2018 to 2026
$1.3M
NIAID NIH HHS 75N93019C00015NIAID NIH HHS HHSN272201700061CNIAID NIH HHS K24 AI134359NIAID NIH HHS P30 AI042853NIAID NIH HHS R01 AI120792NIAID NIH HHS R01 AI147333NIAID NIH HHS R37 AI136058
6 · The paper itself

Abstract

Next-generation sequencing (NGS) is likely to become the new standard method for HIV drug resistance (HIVDR) genotyping. Despite the significant advances in the development of wet-lab protocols and bioinformatic data processing pipelines, one often-missing critical component of an NGS HIVDR assay for clinical use is external quality assessment (EQA). EQA is essential for ensuring assay consistency and laboratory competency in performing routine biomedical assays, and the rollout of NGS HIVDR tests in clinical practice will require an EQA. In September 2019, the 2

Indexed as

Quality Assurance, Health CareCongresses as TopicDiagnostic Tests, RoutineDrug Resistance, ViralGenotypeHigh-Throughput Nucleotide SequencingHIV-1HIV InfectionsSequence Analysis, RNAdrug resistanceexternal quality assessmentHIVnext generation sequencing

Identifiers

PMID32443529
PMCPMC7291315

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.