Evidence map›Paper›PMID 32443406›Full record

ReviewFoods (Basel, Switzerland)2020

Coumarins in Food and Methods of Their Determination.

Mirjana Lončar, Martina Jakovljević, Drago Šubarić, Martina Pavlić, Vlatka Buzjak Služek, Ines Cindrić, Maja Molnar

Abstract readReview
In one paragraph

Review in Foods (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Development of new coumarin-piperazine-N-phenylacetamid derivatives as potent tyrosinase inhibitors: In vitro and in silico evaluations.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Harnessing coumarin-thio(seleno)cyanate conjugates: potentJournal of enzyme inhibition and medicinal chemistry · 2025
    Article
  13. Review
  14. Article
  15. The Antiviral Activity of Polyphenols.Molecular nutrition & food research · 2025
    Review
  16. Review
  17. Article
  18. Article
  19. In Vitro Evaluation of Novel Furo[3,2-Molecules (Basel, Switzerland) · 2025
    Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mirjana LončarFaculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Franje Kuhača 20, 31000 Osijek, Croatia.
Martina JakovljevićFaculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Franje Kuhača 20, 31000 Osijek, Croatia.ORCID 0000-0003-4436-1775
Drago ŠubarićFaculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Franje Kuhača 20, 31000 Osijek, Croatia.
Martina PavlićCroatian Agency for Agriculture and Food, Vinkovačka cesta 63c, 31000 Osijek, Croatia.ORCID 0000-0002-6400-6589
Vlatka Buzjak SlužekCroatian Agency for Agriculture and Food, Vinkovačka cesta 63c, 31000 Osijek, Croatia.
Ines CindrićKarlovac University of Applied Sciences, Trg J. J. Strossmayera 9, 47000 Karlovac, Croatia.
Maja MolnarFaculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Franje Kuhača 20, 31000 Osijek, Croatia.

Funding

European Regional Development Fund Atrium of knowledgeHrvatska Zaklada za Znanost UIP-2017-05-6593
6 · The paper itself

Abstract

Coumarin is a natural product with aromatic and fragrant characteristics, widespread in the entire plant kingdom. It is found in different plant sources such as vegetables, spices, fruits, and medicinal plants including all parts of the plants-fruits, roots, stems and leaves. Coumarin is found in high concentrations in certain types of cinnamon, which is one of the most frequent sources for human exposure to this substance. However, human exposure to coumarin has not been strictly determined, since there are no systematic measurements of consumption of cinnamon-containing foods. The addition of pure coumarin to foods is not allowed, since large amounts of coumarin can be hepatotoxic. However, according to the new European aroma law, coumarin may be present in foods only naturally or as a flavoring obtained from natural raw materials (as is the case with cinnamon). In this paper, the overview of the current European regulations on coumarin levels in food is presented, along with the most common coumarin food sources, with a special emphasis on cinnamon-containing food. Human exposure to coumarins in food is also reviewed, as well as the methods for determination and separation of coumarin and its derivatives in food.

Indexed as

cinnamoncoumarincoumarin-containing foodsdetermination of coumarin in foodhuman exposure to coumarin

Identifiers

PMID32443406
PMCPMC7278589

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.