ArticleDiagnostics (Basel, Switzerland)2020
Thyrotoxic Periodic Paralysis-A Misleading Challenge in the Emergency Department.
Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Article
- The Hidden Crisis: A Rare Case of Thyrotoxicosis in a Young Female, Mimicking Neuromuscular Disease.Journal of community hospital internal medicine perspectives · 2026Article
- When Potassium Takes a Break: A Case Series of 3 Cases on Hypokalemic Periodic Paralysis.Clinical case reports · 2025Article
- Thyrotoxic periodic paralysis in a Caucasian man without identifiable genetic predisposition: a case report.Thyroid research · 2023Article
- A New Scoring System for Predicting Ventricular Arrhythmia Risk in Patients with Acute Myocardial Infarction.Clinical interventions in aging · 2023Article
- Management of hypokalemia in patients with thyrotoxicosis periodic paralysis in Soetomo general hospital: A case report.Annals of medicine and surgery (2012) · 2022Article
- Thyrotoxic periodic paralysis (TPP): assessment in the emergency department.BMJ case reports · 2022Article
- An Unusual Presentation of Thyrotoxicosis: Leg Weakness and Hypokalemia in a 21-Year-Old Male.Case reports in endocrinology · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Despite its' life-threatening potential due to cardiac severe dysrhythmia in the context of severe hypokalemia, thyrotoxic periodic paralysis (TPP) often goes unrecognized. Although classically confined to young Asian men, it can occur irrespective of age, sex, and race. We report a short series of three cases of TPP as first presentation of Graves' disease in a young Caucasian male and in two Caucasian elderly and middle-aged women, respectively. The first patient developed malignant ventricular arrhythmias due to severe hypokalemia and was defibrillated, with recovery after prompt potassium correction and administration of antithyroid agents and propranolol. The other two cases developed persistent hypokalemia despite adequate potassium chloride (KCl) repletion, with slow recovery of motor deficit and serum potassium normalization up to day 5. In the first case, long-term euthyroid state was achieved via total thyroidectomy due to the presence of a suspicious nodule that proved to be malignant. In the other two cases, medical treatment was the choice of therapy for thyrotoxicosis. None experienced recurrent TPP. Thyroid hormone evaluation is mandatory in the presence of hypokalemic paralysis, even in the absence of clinical signs of thyrotoxicosis. If TPP is confirmed, initial therapy should comprise antithyroid drugs and propranolol, besides hypokalemia correction.
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