Evidence map›Paper›PMID 32443389›Full record

Observational studyMedicine2020

Is postoperative hyponatremia a real threat for total hip and knee arthroplasty surgery?

Ennio Sinno, Daniele De Meo, Armando Ugo Cavallo, Luisa Petriello, Daniele Ferraro, Gianluca Fornara, Pietro Persiani, Ciro Villani

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ennio SinnoDepartment of Anatomical, Histological, Forensic Medicine, and Orthopaedic Science, Sapienza University of Rome, Department of Orthopaedics and Traumatology, Policlinico Umberto I.
Daniele De MeoDepartment of Anatomical, Histological, Forensic Medicine, and Orthopaedic Science, Sapienza University of Rome, Department of Orthopaedics and Traumatology, Policlinico Umberto I.
Armando Ugo CavalloDivision of Diagnostic and Interventional Radiology, University Hospital Policlinico "Tor Vergata", Rome, Italy.
Luisa PetrielloDepartment of Anatomical, Histological, Forensic Medicine, and Orthopaedic Science, Sapienza University of Rome, Department of Orthopaedics and Traumatology, Policlinico Umberto I.
Daniele FerraroDepartment of Anatomical, Histological, Forensic Medicine, and Orthopaedic Science, Sapienza University of Rome, Department of Orthopaedics and Traumatology, Policlinico Umberto I.
Gianluca FornaraDepartment of Anatomical, Histological, Forensic Medicine, and Orthopaedic Science, Sapienza University of Rome, Department of Orthopaedics and Traumatology, Policlinico Umberto I.
Pietro PersianiDepartment of Anatomical, Histological, Forensic Medicine, and Orthopaedic Science, Sapienza University of Rome, Department of Orthopaedics and Traumatology, Policlinico Umberto I.
Ciro VillaniDepartment of Anatomical, Histological, Forensic Medicine, and Orthopaedic Science, Sapienza University of Rome, Department of Orthopaedics and Traumatology, Policlinico Umberto I.
Sapienza University of Rome · ITPoliclinico Umberto I · ITPoliclinico Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postoperative hyponatremia (POH) is thought to be a fearsome complication of orthopedic surgery. Primary aim of this cohort study was to evaluate the incidence of POH and its clinical relevance in elective surgery, outlining differences between total knee arthroplasty (TKA) and total hip arthroplasty, looking for the presence of any risk factor commonly related to POH.Four hundred two patients that underwent total hip arthroplasty and total knee arthroplasty performed between 2016 and 2017 were retrospectively examined. Serum electrolytes, hemoglobin, hematocrit, glucose, and creatinine were evaluated preoperatively and at day 0-I-II from surgery. Age, sex, body mass index, comorbidities, drugs, surgery data, transfusions, postoperative symptoms, and length of stay (LOS) were determined. All surgeries were performed by the same equipe. Patients had the same perioperative management, excluded those that took thiazides, already at risk of POH.Patients were divided in 2 groups: group A, patients with normal postoperative natremia (294 patients) and group B, patients who developed POH (108, 26.9%); 66.7% of these developed POH within 24 hours postoperatively. In group B mean postoperative natremia was 133.38 (127.78-134.85) mmol/L. Two patients (1.8%) developed moderate hyponatremia, no severe hyponatremia was documented. Type of surgery, operation time, LOS, and presence of postoperative symptoms did not show statistically significant differences within groups. At multivariate logistic analysis chronic use of thiazides was the only variable associated to a decreased risk of developing POH (OR = 0.39; P = .03). Hemoglobin postoperative values (OR = 1.22; P = .03), the need of postoperative transfusion (OR = 2.50; P = .02) and diabetes (OR = 2.70; P = .01) were associated to an increased risk of POH.Although 26.9% of our patients exhibited POH, the onset of this disorder had no implication on postoperative symptoms and on LOS. Diabetes and transfusion are factors most often associated to POH.

Indexed as

AdultAgedAged, 80 and overAge FactorsArthroplasty, Replacement, HipArthroplasty, Replacement, KneeBlood GlucoseBody Mass IndexComorbidityCreatinineElectrolytesFemaleHematocritHemoglobinsHumansHyponatremiaBlood GlucoseCreatinineElectrolytesHemoglobins

Identifiers

PMID32443389
PMCPMC7253792
OpenAlexW3028234210

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.