Evidence map›Paper›PMID 32442867›Full record

ArticleMedical image analysis2020

Artificial neural networks for magnetic resonance elastography stiffness estimation in inhomogeneous materials.

Jonathan M Scott, Arvin Arani, Armando Manduca, Kiaran P McGee, Joshua D Trzasko, John Huston, Richard L Ehman, Matthew C Murphy

Open access · greenAbstract read
In one paragraph

Article in Medical image analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

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  14. MR elastography: Principles, guidelines, and terminology.Magnetic resonance in medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jonathan M ScottMayo Clinic Medical Scientist Training Program, 200 First Street SW, Rochester 55905, MN, USA.
Arvin AraniDepartment of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester 55905, MN, USA.
Armando ManducaDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester 55905, MN, USA.
Kiaran P McGeeDepartment of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester 55905, MN, USA.
Joshua D TrzaskoDepartment of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester 55905, MN, USA.
John HustonDepartment of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester 55905, MN, USA.
Richard L EhmanDepartment of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester 55905, MN, USA.
Matthew C MurphyDepartment of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester 55905, MN, USA. Electronic address: murphy.matthew@mayo.edu.
Mayo Clinic · US

Funding

Medical Scientist Traning Program at Mayo ClinicT32GM065841 · NIGMS · MAYO CLINIC ROCHESTER · PI KAUFMANN, SCOTT H, SCHIMMENTI, LISA A · 2003 to 2022
$5.8M
High-performance compact 3T MRI: Technical optimization for advanced brain imagingU01EB024450 · NIBIB · MAYO CLINIC ROCHESTER · PI BERNSTEIN, MATTHEW A., FOO, THOMAS K · 2017 to 2021
$5.3M
Magnetic Resonance ElastographyR37EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2016 to 2025
$4.0M
Magnetic Resonance ElastographyR01EB001981 · NIBIB · MAYO CLINIC ROCHESTER · PI EHMAN, RICHARD L. · 2003 to 2013
$3.1M
Advanced preoperative assessment of meningiomasR01EB027064 · NIBIB · MAYO CLINIC ROCHESTER · PI MURPHY, MATTHEW CHRISTOPHER · 2019 to 2022
$1.4M
NIBIB NIH HHS R01 EB001981NIBIB NIH HHS R01 EB027064NIBIB NIH HHS R37 EB001981NIBIB NIH HHS U01 EB024450NIGMS NIH HHS T32 GM065841
6 · The paper itself

Abstract

purposeTo test the hypothesis that removing the assumption of material homogeneity will improve the spatial accuracy of stiffness estimates made by Magnetic Resonance Elastography (MRE).

methodsAn artificial neural network was trained using synthetic wave data computed using a coupled harmonic oscillator model. Material properties were allowed to vary in a piecewise smooth pattern. This neural network inversion (Inhomogeneous Learned Inversion (ILI)) was compared against a previous homogeneous neural network inversion (Homogeneous Learned Inversion (HLI)) and conventional direct inversion (DI) in simulation, phantom, and in-vivo experiments.

resultsIn simulation experiments, ILI was more accurate than HLI and DI in predicting the stiffness of an inclusion in noise-free, low-noise, and high-noise data. In the phantom experiment, ILI delineated inclusions ≤ 2.25 cm in diameter more clearly than HLI and DI, and provided a higher contrast-to-noise ratio for all inclusions. In a series of stiff brain tumors, ILI shows sharper stiffness transitions at the edges of tumors than the other inversions evaluated.

conclusionILI is an artificial neural network based framework for MRE inversion that does not assume homogeneity in material stiffness. Preliminary results suggest that it provides more accurate stiffness estimates and better contrast in small inclusions and at large stiffness gradients than existing algorithms that assume local homogeneity. These results support the need for continued exploration of learning-based approaches to MRE inversion, particularly for applications where high resolution is required.

Indexed as

Elasticity Imaging TechniquesAlgorithmsComputer SimulationHumansMagnetic Resonance ImagingNeural Networks, ComputerPhantoms, ImagingArtificial neural networksInversionMagnetic resonance elastographyStiffness

Identifiers

PMID32442867
PMCPMC7583310
OpenAlexW3019512383

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.