Evidence map›Paper›PMID 32442659›Full record

ArticleJournal of molecular biology2020

Structural and Mechanistic Studies of the Rare Myristoylation Signal of the Feline Immunodeficiency Virus.

Janae B Brown, Holly R Summers, Lola A Brown, Jan Marchant, Paige N Canova, Colin T O'Hern, Sophia T Abbott, Constance Nyaunu, Simon Maxwell, Talayah Johnson and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Janae B BrownHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD 21250, USA.
Holly R SummersHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD 21250, USA.
Lola A BrownHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD 21250, USA.
Jan MarchantHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD 21250, USA.
Paige N CanovaHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD 21250, USA.
Colin T O'HernHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD 21250, USA.
Sophia T AbbottHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD 21250, USA.
Constance NyaunuHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD 21250, USA.
Simon MaxwellHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD 21250, USA.
Talayah JohnsonHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD 21250, USA.
Morgan B MoserHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD 21250, USA.
Sherimay D AblanVirus-Cell Interaction Section, HIV Dynamics and Replication Program, National Cancer Institute at Fredrick, Fredrick, MD 21702-1201, USA.
Hannah CarterVirus-Cell Interaction Section, HIV Dynamics and Replication Program, National Cancer Institute at Fredrick, Fredrick, MD 21702-1201, USA.
Eric O FreedVirus-Cell Interaction Section, HIV Dynamics and Replication Program, National Cancer Institute at Fredrick, Fredrick, MD 21702-1201, USA. Electronic address: efreed@mail.nih.gov.
Michael F SummersHoward Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Maryland Baltimore County, Baltimore, MD 21250, USA. Electronic address: summers@umbc.edu.
Howard Hughes Medical Institute · USUniversity of Maryland, Baltimore County · USNational Cancer Institute · USScience Applications International Corporation (United States) · US

Funding

EXPAND PARTICIPATION BY MINORITIES IN BIOMEDICAL SCIENCER25GM055036 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SUMMERS, MICHAEL FINLEY · 1996 to 2021
$16.9M
HIV-1 Gag Assembly and MaturationZIABC011720 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI FREED, ERIC · 2016 to 2025
$7.2M
REGULATION OF TH2 RESPONSES IN ASTHMAP01AI050498 · NIAID · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI ZURAW, BRUCE L. · 2001 to 2005
$5.7M
NMR Studies of Retroviral Nucleic Acid Binding ProteinsR01AI150498 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI MICHAEL FINLEY SUMMERS · 2020 to 2026
$5.1M
Graduate Training at The Chemistry Biology InterfaceT32GM066706 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SELEY-RADTKE, KATHERINE L, SMITH, AARON T · 2004 to 2023
$3.3M
Retroviral Gag Trafficking, Env Incorporation, and Virus AssemblyZ01BC010775 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI FREED, ERIC · 2007 to 2008
$961k
Howard Hughes Medical InstituteIntramural NIH HHS Z01 BC010775NIAID NIH HHS P01 AI050498NIAID NIH HHS R01 AI150498NIGMS NIH HHS R25 GM055036NIGMS NIH HHS T32 GM066706
6 · The paper itself

Abstract

All retroviruses encode a Gag polyprotein containing an N-terminal matrix domain (MA) that anchors Gag to the plasma membrane and recruits envelope glycoproteins to virus assembly sites. Membrane binding by the Gag protein of HIV-1 and most other lentiviruses is dependent on N-terminal myristoylation of MA by host N-myristoyltransferase enzymes (NMTs), which recognize a six-residue "myristoylation signal" with consensus sequence: M

Indexed as

Amino Acid SequenceAnimalsCatsCell LineCell MembraneGene Products, gagHIV-1HumansImmunodeficiency Virus, FelineMutationMyristic AcidViral Matrix ProteinsVirus AssemblyGene Products, gagMyristic AcidViral Matrix Proteinsfelineimmunodeficiency virusmatrixNMRretrovirus

Identifiers

PMID32442659
PMCPMC7316625
OpenAlexW3028083336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.