ArticleNeuroImage2020
Older adults benefit from more widespread brain network integration during working memory.
Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large-scale resting-state functional brain networks in aging.Psychophysiology · 2023Pooled it
- Cortical activation and functional connectivity during dual-task walking under different cognitive loads: an fNIRS study.Frontiers in human neuroscience · 2026Article
- Increased functional integration of emotional control network across the adult lifespan.Aging brain · 2026Article
- Beyond grip strength: selective slowing of grip force release but not initiation dynamics in a go/no-go target force-matching task.Frontiers in aging neuroscience · 2026Article
- Lateralization Disruption and Dynamic Balance Alterations in Alzheimer's Disease: Impacts on Hemispheric Interaction and Cognitive Performance.Human brain mapping · 2025Article
- A holistic adaptive ageing framework (HAAF) to address complex challenges in ageing.Zeitschrift fur Gerontologie und Geriatrie · 2025Review
- Network topological reorganization mechanisms of primary visual cortex under multimodal stimulation.Frontiers in neuroscience · 2025Article
- Age-related decline in cognitive flexibility and inadequate preparation: evidence from task-state network analysis.GeroScience · 2024Article
- Higher handgrip strength is linked to higher salience ventral attention functional network segregation in older adults.Communications biology · 2024Article
- Age-related reorganization of functional network architecture in semantic cognition.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Age Related Functional Connectivity Signature Extraction Using Energy-Based Machine Learning Techniques.Sensors (Basel, Switzerland) · 2023Article
- Cooperation and competition between the default mode network and frontal parietal network in the elderly.Frontiers in psychology · 2023Article
- Age Differences of the Hierarchical Cognitive Control and the Frontal Rostro-Caudal Functional Brain Activation.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Fatigue Across the Lifespan in Men and Women: State vs. Trait.Frontiers in human neuroscience · 2022Article
- Human immunodeficiency virus-related decreases in corpus callosal integrity and corresponding increases in functional connectivity.Human brain mapping · 2021Article
- Review
- Age-Related Compensatory Reconfiguration of PFC Connections during Episodic Memory Retrieval.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Dedifferentiation of Functional Brain Activation Associated With Greater Visual Discrimination Accuracy in Middle-Aged and Older Adults.Frontiers in aging neuroscience · 2021Article
- What Can Neural Activity Tell Us About Cognitive Resources in Aging?Frontiers in psychology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Neuroimaging evidence suggests that the aging brain relies on a more distributed set of cortical regions than younger adults in order to maintain successful levels of performance during demanding cognitive tasks. However, it remains unclear how task demands give rise to this age-related expansion in cortical networks. To investigate this issue, functional magnetic resonance imaging was used to measure univariate activity, network connectivity, and cognitive performance in younger and older adults during a working memory (WM) task. Here, individuals performed a WM task in which they held letters online while reordering them alphabetically. WM load was titrated to obtain four individualized difficulty levels with different set sizes. Network integration-defined as the ratio of within-versus between-network connectivity-was linked to individual differences in WM capacity. The study yielded three main findings. First, as task difficulty increased, network integration decreased in younger adults, whereas it increased in older adults. Second, age-related increases in network integration were driven by increases in right hemisphere connectivity to both left and right cortical regions, a finding that helps to reconcile existing theories of compensatory recruitment in aging. Lastly, older adults with higher WM capacity demonstrated higher levels of network integration in the most difficult task condition. These results shed light on the mechanisms of age-related network reorganization by demonstrating that changes in network connectivity may act as an adaptive form of compensation, with older adults recruiting a more distributed cortical network as task demands increase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.