Evidence map›Paper›PMID 32442543›Full record

ReviewNeuropharmacology2020

Acetylcholinesterase inhibition resulting from exposure to inhaled OP can be prevented by pretreatment with BChE in both macaques and minipigs.

Yvonne Rosenberg, Ashima Saxena

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuropharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yvonne RosenbergPlantVax Inc., Rockville, MD, 20850, USA. Electronic address: yrosenther@aol.com.
Ashima SaxenaU.S. Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD, 20910, USA.
Walter Reed Army Institute of Research · US

Funding

Efficacy and Safety of an Aerosolized Recombinant Butyrylcholinesterase PretreatmR44NS064608 · NINDS · PLANTVAX, INC. · PI ROSENBERG, YVONNE J · 2013 to 2015
$1.6M
Aerosol Delivery of a Recombinant Butyrylcholinesterase "BioShield" to Protect AgU44NS064608 · NINDS · PLANTVAX, INC. · PI ROSENBERG, YVONNE J · 2009 to 2012
$1.5M
NINDS NIH HHS R44 NS064608NINDS NIH HHS U44 NS064608
6 · The paper itself

Abstract

More frequent and widespread nerve agent attacks highlight the need for efficacious pre- and post-exposure organophosphate (OP) counter-measures to protect military and civilian populations. Because of critical targeting of acetylcholinesterase (AChE) in the CNS by OPs, a pre-treatment candidate for preventing/reducing poisoning will be a broadly acting molecule that scavenges OPs in blood before they reach their physiological targets. Prophylactic human butyrylcholinesterase (HuBChE), the leading pretreatment candidate, has been shown to protect against multiple LD

Indexed as

Inhalation ExposureAcetylcholinesteraseAnimalsButyrylcholinesteraseCholinesterase InhibitorsHumansMacacaOrganophosphatesSpecies SpecificitySwineSwine, MiniatureAcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsOrganophosphatesButyrylcholinesteraseInhalation exposureMacaqueMinipigNeurotoxicityOrganophosphatePretreatmentProtectionVibrating mesh nebulizer

Identifiers

PMID32442543
PMCPMC7365266
OpenAlexW3026087880

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.